Psychiatry Investig.  2020 Feb;17(2):163-174. 10.30773/pi.2019.0240.

Defining Treatment Response, Remission, Relapse, and Recovery in First-Episode Psychosis: A Survey among Korean Experts

  • 1Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea
  • 2Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea
  • 3Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, Republic of Korea
  • 4Department of Psychiatry, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Republic of Korea
  • 5Department of Psychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea
  • 6Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, Republic of Korea
  • 7Department of Psychiatry, Inje University College of Medicine, Goyang, Republic of Korea
  • 8Department of Psychiatry, Korea University College of Medicine, Guro Hospital, Seoul, Republic of Korea
  • 9Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea
  • 10Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • 11Department of Occupational and Environmental Medicine, Institute of Environmental and Occupational Medicine, Busan Paik Hospital, Inje University, Busan, Republic of Korea
  • 12Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Republic of Korea
  • 13Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea


For the proper treatment of first-episode psychosis, assessment of treatment response, remission, relapse, and recovery is important. Therefore, the present study aimed to develop operational definitions of clinical outcomes in first-episode psychosis.
A questionnaire was developed by a panel of experts and underwent three revisions. The final survey was presented to 150 psychiatrists who were members of the Korean Society for Schizophrenia Research. Respondents selected factors that they believed were important to consider while defining treatment response, remission, relapse, and recovery using a 6-point Likert scale. Selected factors that constituted each definition were statistically extracted, and operational definitions were developed.
A total of 91 experts responded to the survey. The extent of reduction in psychopathology, socio-occupational functioning, and duration of each state were the core factors of each definition. Outcomes obtained from discussions and consultations by experts have been summarized and proposed.
The criteria developed in this survey tended to be somewhat stricter than those used by other studies. The fundamental reason for this is that this survey focused on first-episode psychosis. A better understanding of each definition in first-episode psychosis is necessary to improve effective treatment outcomes.


First-episode psychosis, Treatment response, Remission, Relapse, Recovery, Definition
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