Int Neurourol J.  2020 May;24(Suppl 1):S3-10. 10.5213/inj.2040150.075.

Stem Cell Therapy for Neurogenic Bladder After Spinal Cord Injury: Clinically Possible?

Affiliations
  • 1Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea
  • 2Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 3Department of Urology, Chungnam National University Sejong Hospital, Chungnam National University College of Medicine, Sejong, Korea
  • 4Department of Urology, Gachon University Gil Medical Center, Gachon University of School of Medicine, Incheon, Korea

Abstract

Neurogenic bladder (NB) after spinal cord injury (SCI) is a common complication that inhibits normal daily activities and reduces the quality of life. Regrettably, the current therapeutic methods for NB are inadequate. Therefore, numerous studies have been conducted to develop new treatments for NB associated with SCI. Moreover, a myriad of preclinical and clinical trials on the effects and safety of stem cell therapy in patients with SCI have been performed, and several studies have demonstrated improvements in urodynamic parameters, as well as in sensory and motor function, after stem cell therapy. These results are promising; however, further high-quality clinical studies are necessary to compensate for a lack of randomized trials, the modest number of participants, variation in the types of stem cells used, and inconsistency in routes of administration.

Keyword

Urinary bladder; Neurogenic; Spinal cord injury; Stem cells, Clinical trials
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