Korean J Radiol.  2020 Apr;21(4):450-461. 10.3348/kjr.2019.0499.

Cardiac CT for Measurement of Right Ventricular Volume and Function in Comparison with Cardiac MRI: A Meta-Analysis

Affiliations
  • 1Department of Radiology, Dongsan Hospital, Keimyung University College of Medicine, Daegu, Korea.
  • 2Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. rongzusuh@gmail.com

Abstract


OBJECTIVE
We performed a meta-analysis to evaluate the agreement of cardiac computed tomography (CT) with cardiac magnetic resonance imaging (CMRI) in the assessment of right ventricle (RV) volume and functional parameters.
MATERIALS AND METHODS
PubMed, EMBASE, and Cochrane library were systematically searched for studies that compared CT with CMRI as the reference standard for measurement of the following RV parameters: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), or ejection fraction (EF). Meta-analytic methods were utilized to determine the pooled weighted bias, limits of agreement (LOA), and correlation coefficient (r) between CT and CMRI. Heterogeneity was also assessed. Subgroup analyses were performed based on the probable factors affecting measurement of RV volume: CT contrast protocol, number of CT slices, CT reconstruction interval, CT volumetry, and segmentation methods.
RESULTS
A total of 766 patients from 20 studies were included. Pooled bias and LOA were 3.1 mL (−5.7 to 11.8 mL), 3.6 mL (−4.0 to 11.2 mL), −0.4 mL (5.7 to 5.0 mL), and −1.8% (−5.7 to 2.2%) for EDV, ESV, SV, and EF, respectively. Pooled correlation coefficients were very strong for the RV parameters (r = 0.87-0.93). Heterogeneity was observed in the studies (I2 > 50%, p < 0.1). In the subgroup analysis, an RV-dedicated contrast protocol, ≥ 64 CT slices, CT volumetry with the Simpson's method, and inclusion of the papillary muscle and trabeculation had a lower pooled bias and narrower LOA.
CONCLUSION
Cardiac CT accurately measures RV volume and function, with an acceptable range of bias and LOA and strong correlation with CMRI findings. The RV-dedicated CT contrast protocol, ≥ 64 CT slices, and use of the same CT volumetry method as CMRI can improve agreement with CMRI.

Keyword

Right ventricular function; Volumetry; Computed tomography; Magnetic resonance imaging; Meta-analysis

MeSH Terms

Bias (Epidemiology)
Heart Ventricles
Humans
Loa
Magnetic Resonance Imaging*
Methods
Papillary Muscles
Population Characteristics
Stroke Volume
Ventricular Function, Right
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