Obstet Gynecol Sci.  2020 Mar;63(2):173-180. 10.5468/ogs.2020.63.2.173.

The effect of ginger and metoclopramide in the prevention of nausea and vomiting during and after surgery in cesarean section under spinal anesthesia

Affiliations
  • 1Department of Obstetrics and Gynecology, Qazvin University of Medical Sciences, Qazvin, Iran. Lalooha44@yahoo.com
  • 2Department of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • 3Rocky Vista University College of Osteopathic Medicine, Parker, CO, USA.
  • 4Infertility and Reproductive Health Research Center, Shahid Beheshti Medical University, Tehran, Iran.
  • 5Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.

Abstract


OBJECTIVE
Postoperative nausea and vomiting is one of the most common side effects after anesthesia in surgeries, such as cesarean section. This study aimed to investigate the effect of ginger and metoclopramide in the prevention of nausea and vomiting during and after cesarean section.
METHODS
This clinical trial was conducted on 180 patients aged 18-40 years who underwent cesarean section under spinal anesthesia. The first group received 10 mg of metoclopramide via intravenous injection (metoclopramide group), and the second group received 1 g of oral ginger (ginger group) half an hour before spinal anesthesia. The frequency and severity of nausea and vomiting during surgery and at 2, 6, 12, and 24 hours postoperatively were compared in both groups. To analyze the results, the t-test, chi-square test, and Mann-Whitney test were used.
RESULTS
There was no significant difference in the frequency of nausea and vomiting between the 2 groups during operation, 2 hours and 6 hours after surgery (P=0.182, 0.444 and 0.563 respectively). The severity of nausea and vomiting was also similar in the 2 groups (P=0.487 and 0.652 respectively); however, the metoclopramide group had a lower systolic blood pressure (P<0.001; df=2.176; f=18.66) and mean arterial pressure (P<0.001; df=2.176; f=6.36) than the ginger group.
CONCLUSION
The results revealed that ginger reduced nausea and vomiting to the same extent as metoclopramide in patients undergoing cesarean section. TRIAL REGISTRATION: Iranian Center for Clinical Trials Identifier: IRCT201611028611N3

Keyword

Cesarean section; Spinal anesthesia; Metoclopramide; Ginger

MeSH Terms

Anesthesia
Anesthesia, Spinal*
Arterial Pressure
Blood Pressure
Cesarean Section*
Female
Ginger*
Humans
Injections, Intravenous
Metoclopramide*
Nausea*
Postoperative Nausea and Vomiting
Pregnancy
Vomiting*
Metoclopramide
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