Pediatr Gastroenterol Hepatol Nutr.  2020 Mar;23(2):154-162. 10.5223/pghn.2020.23.2.154.

Cow's Milk-Related Symptom Score in Presumed Healthy Polish Infants Aged 0–6 Months

• Bigorajska K
• Filipiak Z
• Winiarska
• Adamiec A
• Trent B
• Vandenplas Y
• RuszczyÅ„ski M
• Szajewska

• KMID: 2471625
• DOI: http://doi.org/10.5223/pghn.2020.23.2.154

Abstract

PURPOSE
The Cow's Milk-related Symptom Score (CoMiSS™), which considers crying, regurgitation, stools, skin and respiratory symptoms, was developed as an awareness tool for evaluating cow's milk-related symptoms. The scoring ranges from 0 to 33. A score ≥12 was proposed as being likely cow's milk-related and suggestive of allergy to cow's milk. This study aimed to determine the age-related CoMiSS™ values in presumed healthy infants in Poland.
METHODS
This was a cross-sectional study conducted in well-child clinics in two locations. Parents of the presumed healthy infants aged ≤6 months were approached during a routine checkup/vaccination visit. The exclusion criteria were as follows: presence of acute or chronic diseases, preterm delivery, treatment with therapeutic formula, and use of any food supplements (except vitamins) or medications.
RESULTS
Data from 226 infants were obtained (median age [Q1-Q3], 4 months [3-4]). The overall median (Q1-Q3) and mean (standard deviation) CoMiSS™ values were 4 (2-7) and 4.7 (3.5), respectively. The 95th percentile was 11. Scores on some, albeit not all, components of the CoMiSS™ significantly differed between age groups (crying, stools) or feeding type groups (stools and skin symptoms). Eleven children (4.9%) scored ≥12.
CONCLUSION
This study adds to earlier age-related CoMiSSâ„¢ data by providing CoMiSSâ„¢ values in presumed healthy infants in Poland.

Keyword

Infant; Milk; Food allergy; Food hypersensitivity

MeSH Terms

Child
Chronic Disease
Cross-Sectional Studies
Crying
Dietary Supplements
Food Hypersensitivity
Humans
Hypersensitivity
Infant*
Milk
Parents
Poland
Skin

Figure

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  Fig. 1 Distribution of Cow's Milk-related Symptom Score (CoMiSS™) total scores.

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  Fig. 2 Distribution of Cow's Milk-related Symptom Score (CoMiSS™) individual scores by sex.

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  Fig. 3 Distribution of Cow's Milk-related Symptom Score (CoMiSS™) individual scores by age.

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  Fig. 4 Distribution of Cow's Milk-related Symptom Score (CoMiSS™) individual scores by the type of feeding.

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