J Korean Orthop Assoc.  2020 Feb;55(1):9-28. 10.4055/jkoa.2020.55.1.9.

Current Guidelines for Non-Steroidal Anti-Inflammatory Drugs

  • 1Department of Orthopedic Surgery, Ewha Womans University Mokdong Hospital, Seoul, Korea. koreanknee@gmail.com


Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide for chronic pain, such as arthritis, and there are many different types depending on their composition and mechanism. After long-term use, various side effects can occur, such as gastrointestinal and cardiovascular complications. With a similar analgesic effect to that of traditional non-selective NSAIDs, cyclooxygenase-2-selective NSAIDs have been highly anticipated, because they could complement gastrointestinal tolerance. On the other hand, because of concerns about cardiovascular safety in 2004 and 2005, and the license withdrawals of rofecoxib and valdecoxib, the interest in the side effects of NSAIDs is increasing. Therefore, it is important to use the necessary drugs at a minimum, considering the side effects and interactions of each drug. This study examined the side effects and characteristics of each NSAID that may occur and reviewed the recent research and guidelines related to the use of non-selective NSAIDs and cyclooxygenase-2-selective NSAIDs.


anti-inflammatory agents; non steroidal; drug-related side effects and adverse reactions; drug therapy
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