J Lab Med Qual Assur.  2019 Dec;41(4):201-206. 10.15263/jlmqa.2019.41.4.201.

Current Status of Estimated Glomerular Filtration Rate Reporting in Korea

Affiliations
  • 1Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, Korea. tdjeong@ewha.ac.kr
  • 2Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
  • 3Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

Abstract

BACKGROUND
We aimed to investigate the current status of estimated glomerular filtration rate (eGFR) reporting in clinical laboratories for the first time in Korea.
METHODS
The eGFR proficiency testing data obtained by the Korean Association of External Quality Assessment Service (KEQAS) from 2017 to 2018 as a pilot project were used. We investigated the proportion of clinical laboratories reporting eGFR who were participants in the KEQAS general chemistry proficiency testing program. The types of equations for calculating the eGFR in adults and children were assessed. We evaluated whether each participant laboratory calculated the eGFR correctly.
RESULTS
About 18% and 12% of laboratories were reporting the eGFR with serum creatinine concentrations for adults and children, respectively. The most common equation for calculating the eGFR in adults was the Modification of Diet in Renal Disease (MDRD) 4 variable (isotope dilution mass spectrometry [IDMS]-traceable), followed by the MDRD 4 variable (non-IDMS-traceable) and Chronic Kidney Disease-Epidemiology Collaboration equation. In children, 9% used the original Schwartz, 4% used the updated Schwartz, and the other laboratories used the same equation as adults. Accurate eGFR was calculated in 76.0%–96.2% of adults and 65.3%–75.0% of children.
CONCLUSIONS
Continuous education is needed to report eGFR in clinical laboratories that measure serum creatinine levels. Clinical laboratories need to report the eGFR in accordance with internationally recommended guidelines.

Keyword

Creatinine; Glomerular filtration rate; Laboratory proficiency testing
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