Pediatr Gastroenterol Hepatol Nutr.  2020 Jan;23(1):72-78. 10.5223/pghn.2020.23.1.72.

Infantile Hepatic Hemangioma: Avoiding Unnecessary Invasive Procedures

Affiliations
  • 1Department of Pediatrics, Hospital Barmherzige Brüder, Regensburg, Germany.
  • 2Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • 3Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. jtrah@uke.de

Abstract

Infantile hepatic hemangioma, the most common vascular tumor of the liver in infancy, can occur with acute postnatal liver and congestive heart failure. Nevertheless, its course is often benign, and many children can be diagnosed and treated without surgical intervention. The distinction from malignant diseases is not always easy and it not clear whether invasive procedures for diagnosis and therapy should be performed. Here we report our experiences in our Center for Pediatric Liver Disease and postulate that large studies are needed to avoid unnecessary invasive procedures for these patients in the future.

Keyword

Hemangioma; Liver; Vascular malformations; Deletion; Infant; Children; Vascular neoplasms

MeSH Terms

Child
Diagnosis
Heart Failure
Hemangioma*
Humans
Infant
Liver
Liver Diseases
Vascular Malformations
Vascular Neoplasms

Reference

1. Avagyan S, Klein M, Kerkar N, Demattia A, Blei F, Lee S, et al. Propranolol as a first-line treatment for diffuse infantile hepatic hemangioendothelioma. J Pediatr Gastroenterol Nutr. 2013; 56:e17–20. PMID: 22331019.
Article
2. Blohm ME, Vesterling-Hörner D, Calaminus G, Göbel U. Alpha 1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol. 1998; 15:135–142. PMID: 9592840.
3. Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, et al. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg. 2007; 42:62–67. discussion 67-8. PMID: 17208542.
Article
4. Dachman AH, Lichtenstein JE, Friedman AC, Hartman DS. Infantile hemangioendothelioma of the liver: a radiologic-pathologic-clinical correlation. AJR Am J Roentgenol. 1983; 140:1091–1096. PMID: 6602472.
Article
5. Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ, et al. History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis. World J Clin Pediatr. 2016; 5:273–280. PMID: 27610342.
Article
6. Grisotti G, Cowles RA. Complications in pediatric hepatobiliary surgery. Semin Pediatr Surg. 2016; 25:388–394. PMID: 27989363.
Article
7. Kawahara Y, Nijima H, Suzuki Y, Furukawa R, Morimoto A. Successful use of propranolol for congenital hepatic hemangioma with Kasabach-Merritt phenomenon. Pediatr Int. 2017; 59:634–636. PMID: 28402071.
Article
8. Kulungowski AM, Alomari AI, Chawla A, Christison-Lagay ER, Fishman SJ. Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg. 2012; 47:165–170. PMID: 22244411.
Article
9. Kuroda T, Kumagai M, Nosaka S, Nakazawa A, Takimoto T, Hoshino K. Infantile Hepatic Hemangioma Study Group, Japan. Critical infantile hepatic hemangioma: results of a nationwide survey by the Japanese Infantile Hepatic Hemangioma Study Group. J Pediatr Surg. 2011; 46:2239–2243. PMID: 22152857.
Article
10. Mahajan P, Margolin J, Iacobas I. Kasabach-Merritt phenomenon: classic presentation and management options. Clin Med Insights Blood Disord. 2017; 10:1179545X17699849.
Article
11. Marler JJ, Fishman SJ, Upton J, Burrows PE, Paltiel HJ, Jennings RW, et al. Prenatal diagnosis of vascular anomalies. J Pediatr Surg. 2002; 37:318–326. PMID: 11877641.
Article
12. Mazereeuw-Hautier J, Hoeger PH, Benlahrech S, Ammour A, Broue P, Vial J, et al. Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis. J Pediatr. 2010; 157:340–342. PMID: 20488455.
Article
13. Mizutani K, Umaoka A, Tsuda K, Kakeda M, Habe K, Yamanaka K, et al. Successful combination therapy of propranolol and prednisolone for a case with congenital Kasabach-Merritt syndrome. J Dermatol. 2017; 44:1389–1391. PMID: 28771780.
Article
14. Mo JQ, Dimashkieh HH, Bove KE. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol. 2004; 35:200–209. PMID: 14991538.
Article
15. Moon SB, Kwon HJ, Park KW, Yun WJ, Jung SE. Clinical experience with infantile hepatic hemangioendothelioma. World J Surg. 2009; 33:597–602. PMID: 19132441.
Article
16. Mulliken JB, Glowacki J. Classification of pediatric vascular lesions. Plast Reconstr Surg. 1982; 70:120–121. PMID: 7089103.
17. Patiño-Seijas B, Lorenzo-Franco F, Rey-Sanjurjo JL, González-Cuesta M, López-Cedrún Cembranos JL. Vascular Lesions: GLUT-1 expression as a diagnostic tool to discriminate tumors from malformations. J Oral Maxillofac Surg. 2012; 70:2333–2342. PMID: 22330334.
Article
18. Iacobas I, Phung TL, Adams DM, Trenor CC 3rd, Blei F, Fishman DS, et al. Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring. J Pediatr. 2018; 203:294–300.e2. PMID: 30244993.
Article
19. Sari N, Yalçin B, Akyüz C, Haliloglu M, Büyükpamukçu M. Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein. Pediatr Hematol Oncol. 2006; 23:639–647. PMID: 17065140.
20. Schneider DT, Calaminus G, Göbel U. Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood. Pediatr Hematol Oncol. 2001; 18:11–26. PMID: 11205836.
21. Sevinir B, Ozkan TB. Infantile hepatic hemangioendothelioma: clinical presentation and treatment. Turk J Gastroenterol. 2007; 18:182–187. PMID: 17891692.
22. Thampy R, Elsayes KM, Menias CO, Pickhardt PJ, Kang HC, Deshmukh SP, et al. Imaging features of rare mesenychmal liver tumours: beyond haemangiomas. Br J Radiol. 2017; 90:20170373. PMID: 28766950.
Article
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