Psychiatry Investig.  2019 Nov;16(11):829-835. 10.30773/pi.2019.0232.

Similarities of Aspects of Biological Rhythms between Major Depression and Bipolar II Disorder Compared to Bipolar I Disorder: A Finding from the Early-Onset Mood Disorder Cohort

  • 1Department of Psychiatry, Biomedical Science, Korea University College of Medicine, Seoul, Republic of Korea.
  • 2Chronobiology Institute, Korea University, Seoul, Republic of Korea.
  • 3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • 4Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • 5Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • 6Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
  • 7Department of Psychiatry, Busan National University School of Medicine, Busan, Republic of Korea.
  • 8Department of Psychiatry, National Center for Mental Health, Seoul, Republic of Korea.
  • 9Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • 10Department of Psychiatry, Chonnam National University College of Medicine, Gwangju, Republic of Korea.
  • 11Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea.


The biological rhythm is closely related to mood symptoms. The purpose of this study was to assess the differences in biological rhythms among subjects with mood disorder [bipolar I disorder (BD I), bipolar II disorder (BD II), major depressive disorder (MDD)] and healthy control subjects.
A total of 462 early-onset mood disorder subjects were recruited from nine hospitals. The controls subjects were recruited from the general population of South Korea. Subject groups and control subject were evaluated for the Korean language version of Biological Rhythms Interview of Assessment in Neuropsychiatry (K-BRIAN) at the initial evaluation.
The mean K-BRIAN scores were 35.59 [standard deviation (SD)=13.37] for BD I, 43.05 (SD=11.85) for BD II, 43.55 (SD=12.22) for MDD, and 29.1 (SD=8.15) for the control group. In the case of mood disorders, biological rhythm disturbances were greater than that in the control group (p<0.05). A significant difference existed between BD I and BD II (BD I CONCLUSION
BD II and MDD are similar to each other but different from BD I in biological rhythm patterns in early-onset mood disorder cases. Biological rhythm disturbances are similar for early-onset major depression and BD II.


Biological rhythm; Bipolar disorder; Major depressive disorder; Cohort

MeSH Terms

Bipolar Disorder
Cohort Studies*
Depressive Disorder, Major
Mood Disorders*
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