Allergy Asthma Respir Dis.  2019 Oct;7(4):218-221. 10.4168/aard.2019.7.4.218.

A case of hair dye-induced contact anaphylaxis

Affiliations
  • 1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. helenmed@snu.ac.kr
  • 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Abstract

Anaphylaxis is a sudden-onset life-threatening systemic hypersensitivity reaction. Allergens, such as foods, stinging insect venoms, and drugs, are the globally important causative factors for anaphylaxis. Para-phenylenediamine (PPD), an aromatic amine, is a well-known hair dye component that can act as a skin irritant and/or a skin sensitizer. As an allergen, PPD can induce various reactions; the most common being contact dermatitis, a delayed-type hypersensitivity reaction. Anaphylaxis or other immediate hypersensitivity reactions by hair dye contact is extremely rare, with only a few cases reported worldwide. Here, we report a case of a 63-year-old female who presented to the Emergency Department with dyspnea, rash, vomiting, and diarrhea within minutes after using a hair dye product containing PPD. Her past medical history includes urticaria of unknown cause. Her total IgE antibody level was increased to 630 kU/L. Skin prick and patch tests with the hair dye she applied at the time of anaphylaxis demonstrated an immediate reaction. An additional patch test with 25 common contact allergens showed positive reaction to PPD. This is the first case report of hair dye-induced contact anaphylaxis presenting sensitization to PPD in Korea.

Keyword

Anaphylaxis; Hair dyes; Para-phenylenediamine

MeSH Terms

Allergens
Anaphylaxis*
Bites and Stings
Dermatitis, Contact
Diarrhea
Dyspnea
Emergency Service, Hospital
Exanthema
Female
Hair Dyes
Hair*
Humans
Hypersensitivity
Hypersensitivity, Immediate
Immunoglobulin E
Insects
Korea
Middle Aged
Patch Tests
Skin
Urticaria
Venoms
Vomiting
Allergens
Hair Dyes
Immunoglobulin E
Venoms
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