Asia Pac Allergy.
2019 Oct;9(4):e30. 10.5415/apallergy.2019.9.e30.
IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset
- Affiliations
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- 1Centre Hospitalier Universitaire de Montpellier, Hôpital Arnaud-de-Villeneuve, Département de Pneumologie et Addictologie, unité Exploration des Allergies, 34295 Montpellier, France. a-chiriac@chu-montpellier.fr
- 2Serviço de Imunoalergologia, Centro Hospitalar de São João E.P.E; Porto, Portugal.
- 3Sorbonne Université, INSERM, Institut Pierre-Louis D'épidémiologie et de Santé Publique, équipe EPAR, 75013 Paris, France.
- KMID: 2461102
- DOI: http://doi.org/10.5415/apallergy.2019.9.e30
Abstract
- Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption. Most DHR are IgE-mediated, with half of the reactions being anaphylactic. We describe the case of a Caucasian 50-year-old female patient referred to our allergy department after 2 episodes of anaphylaxis. The allergy work-up distinguished PPI as a cause of delayed onset (14 hours) and immediate onset (45 minutes) IgE-mediated DHR.
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