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Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age Children with Gastroesophageal Reflux Symptoms?

Yang J, Lee J, Lee H, Lee J, Youn YM, Choi JH, Kim YJ, Kang HS, Han KH, Kim SH, Kang KS

PURPOSE: On the basis of evidence, we aimed to reevaluate the necessity of the empirical proton pump inhibitor (PPI) trial for children with suspected gastroesophageal reflux disease (GERD). METHODS: We analyzed...
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Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients

Kim SY, Lee NM, Yun SW, Chae SA, Lim IS, Choi ES, Yi DY

BACKGROUND: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed. PURPOSE: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children...
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Can proton pump inhibitors cause intestinal inflammation in children?

Kang B

No abstract available.
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IgE-mediated allergy to proton pump inhibitors with both delayed and immediate onset

Barakat L, Vasconcelos MJ, Bourrain J, Demoly P, Chiriac AM

Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases. Incidence of drug hypersensitivity reactions (DHRs) to PPIs has been rising, presumably because of their increased consumption....
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Association of Proton Pump Inhibitor Use and Risk of Fracture Based on the National Health Insurance Sample Cohort Database (2002~2013)

Kim JJ, Jang EJ, Cho J, Sohn HS

OBJECTIVES: The purpose of this study was to investigate the association between fracture risk and proton pump inhibitor (PPI) use to establish evidence for defining high-risk groups of fracture among...
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Gastro Oesophageal Reflux Disease Shadowing Anxiety Disorder Causing Prolonged Exposure to Proton Pump Inhibitor

Tahir NS, Zakaria R, Draman N

Anxiety disorders are the most prevalent psychiatric disorders in the general population. The relationship between dyspepsia and particularly gastroesophageal reflux disease (GERD) and psychiatric comorbidity such as anxiety is poorly...
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Issues on the Stress Ulcer Prophylaxis Using Proton Pump Inhibitor in Intensive Care Unit

Cho JH, Shin CM

No abstract available.
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Proton pump inhibitor intake negatively affects the osseointegration of dental implants: a retrospective study

Altay MA, Sindel A, Özalp O, Yıldırımyan N, Kocabalkan B

OBJECTIVES: This study sought to investigate the association between the systemic intake of proton pump inhibitors (PPI) and the early failure of dental implants. MATERIALS AND METHODS: A retrospective cohort study...
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Effects of Proton Pump Inhibitor for Laryngopharyngeal Reflux and Comorbid Chronic Rhinosinusitis

Jung HJ, Kim JH, Kang MH, Lee DW

BACKGROUND AND OBJECTIVES: Laryngopharyngeal reflux (LPR) is a prevalent condition with an increasing incidence, and several recent studies have reported the association of LPR with chronic rhinosinusitis (CRS). In this...
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Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker

Mori H, Suzuki H

  • KMID: 2433493
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):6-14.
  • doi: 10.5056/jnm18139
Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related diseases, such as gastroesophageal reflux disease, peptic ulcer disease, and Helicobacter pylori infection, and for the prevention of...
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Standard First-line Triple Therapy for Helicobacter pylori Infection: A Comparison of Eradication Rates Based on Timing of Administration of Proton Pump Inhibitors

Lee SJ, Lim YJ, Hong SB, Nam JH, Jang DK, Kang HW, Kim JH, Lee JK, Koh MS, Lee JH

BACKGROUND/AIMS: Recent Korean studies performed over the past few decades have shown diminishing efficacy and unacceptability of clarithromycin-based triple therapy as first-line eradication therapy for Helicobacter pylori infection, based on...
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Is It More Effective to Prescribe a Proton Pump Inhibitor Separately before a Meal for the Eradication of Helicobacter pylori?

Lee GW, Kim JH, Moon W, Park SJ, Park MI, Kim SE, Kwon HJ, Choi YJ

BACKGROUND/AIMS: The current standard regimen for the treatment of Helicobacter pylori infection is a combination of a proton pump inhibitor (PPI), amoxicillin, and clarithromycin. The aim of this study was...
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Is It Better to Take a Proton Pump Inhibitor before a Meal for Helicobacter pylori Eradication?

Kim TH

No abstract available.
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Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use

Kinoshita , Ishimura N, Ishihara S

  • KMID: 2413095
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):182-196.
  • doi: 10.5056/jnm18001
Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases including gastroesophageal reflux disease and secondary prevention of aspirin/NSAID-induced ulcers. Although clinically...
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Association of proton pump inhibitor use with renal outcomes in patients with coronary artery disease

Cho NJ, Choi CY, Park S, Park SH, Lee EY, Gil HW

BACKGROUND: Several studies have suggested that proton pump inhibitor (PPI) use is associated with adverse renal outcomes, but obvious evidence for this association is lacking. We investigated the association between...
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Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?

Belei O, Olariu L, Dobrescu A, Marcovici , Marginean

  • KMID: 2417272
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):51-57.
  • doi: 10.5056/jnm17059
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a frequent condition diagnosed in children and treated with proton pump inhibitors (PPI). Long-term PPI administration can alter intestinal bacterial population by suppressing the...
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Esophageal Baseline Impedance Reflects Mucosal Integrity and Predicts Symptomatic Outcome With Proton Pump Inhibitor Treatment

Xie C, Sifrim D, Li Y, Chen M, Xiao Y

  • KMID: 2417271
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):43-50.
  • doi: 10.5056/jnm17032
BACKGROUND/AIMS: Esophageal baseline impedance, which is decreased in gastroesophageal reflux disease (GERD) patients, is related to the severity of acid reflux and the integrity of the esophageal mucosa. The study...
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Can Esophageal Baseline Impedance Predict Proton Pump Inhibitor Response in Gastroesophageal Reflux Disease?

Jung K, Park MI

  • KMID: 2417266
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):1-3.
  • doi: 10.5056/jnm17138
No abstract available.
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Additive Effects of Rebamipide Plus Proton Pump Inhibitors on the Expression of Tight Junction Proteins in a Rat Model of Gastro-Esophageal Reflux Disease

Gweon TG, Park JH, Kim BW, Choi YK, Kim JS, Park SM, Kim CW, Kim HG, Chung JW, Incheon and Western Kyonggi Gastrointestinal Study Group

BACKGROUND/AIMS: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). METHODS:...
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Effectiveness of Proton Pump Inhibitor in the Treatment of Contact Granuloma

Kim DH, Kim KH, Jung SM, Song CM, Ji YB, Tae K

BACKGROUND AND OBJECTIVES: Contact granuloma is granulation tissue that occurs mainly in the vocal process of arytenoid cartilage. Among several etiological factors, gastric acid reflux is known to be an...
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