Ann Dermatol.  2019 Oct;31(5):559-562. 10.5021/ad.2019.31.5.559.

Syringocystadenocarcinoma Papilliferum: A Case Report and Review of the Literature

Affiliations
  • 1Department of Dermatology, College of Medicine, Konyang University, Daejeon, Korea. mabie@hanmail.net

Abstract

Syringocystadenocarcinoma papilliferum (SCACP) is a rare malignant adnexal neoplasm, which is considered as a malignant counterpart of syringocystadenoma papilliferum (SCAP). Clinically, SCACP appears as a nodule, inflammatory plaque, or tumor. The lesion is usually covered with crusts, which are formed by secretion of the apocrine epithelial cells. Histologically, SCACP resembles SCAP, with cystic papillomatous invaginations connected to the skin surface by funnel-shaped structures lined by infundibular epithelium. The stroma of the tumor consists of a dense inflammatory infiltrate of plasma cells and lymphocytes. SCACP differs from SCAP in terms of the architectural and cytological features of the tumor cells, and is characterized by higher nuclear cytoplasmic ratio, nuclear irregularity, coarse chromatin, and increased mitotic activity. However, the immunohistochemical findings of SCACP vary. Since only 49 cases of SCACP have been reported in the English literature, the clinical and histologic characteristics of SCACP have not been fully established. Further studies on the diagnostic criteria for SCACP are warranted. Here, we report a rare case of SCACP and present a review of other relevant literature.

Keyword

Sweat gland neoplasm; Syringocystadenocarcinoma papilliferum; Syringocystadenoma papilliferum

MeSH Terms

Chromatin
Cytoplasm
Epithelial Cells
Epithelium
Lymphocytes
Plasma Cells
Skin
Sweat Gland Neoplasms
Chromatin
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr