Psychiatry Investig.
2019 Jun;16(6):469-474. 10.30773/pi.2019.04.02.2.
Altered Plasma Levels of Glial Cell Line-Derived Neurotrophic Factor in Patients with Internet Gaming Disorder: A Case-Control, Pilot Study
- Affiliations
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- 1Department of Psychiatry, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea.
- 2Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, Republic of Korea.
- 3Addiction Laboratory, Department of Psychiatry, College of Medicine, The Catholic of University of Korea, Seoul, Republic of Korea.
- 4Department of Psychology, Korea University, Seoul, Republic of Korea.
- 5Department of Psychiatry, SMU-SNU Boramae Medical Center, Seoul, Republic of Korea.
- 6Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
- 7Department of Psychiatry, True Mind Mental Health Clinic, Seoul, Republic of Korea.
- 8Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. kdj922@chollian.net
- KMID: 2451943
- DOI: http://doi.org/10.30773/pi.2019.04.02.2
Abstract
- Glial cell line-derived neurotrophic factor (GDNF) has been reported to be involved in negatively regulating the effects of addictive disorders. The objective of this study was to investigate alterations in the levels of GDNF in patients with Internet gaming disorder (IGD) and to assess the relationship between GDNF levels and the severity of IGD indices. Nineteen male patients with IGD and 19 sexmatched control subjects were evaluated for alteration of plasma GDNF levels and for relationship between GDNF levels and clinical characteristics of Internet gaming, including the Young's Internet Addiction Test (Y-IAT). The GDNF levels were found to be significantly low in patients with IGD (103.2±62.0 pg/mL) compared with the levels of controls (245.2±101.6 pg/mL, p<0.001). GDNF levels were negatively correlated with Y-IAT scores (Spearman's rho=-0.645, p=<0.001) and this negative correlation remained even after controlling for multiple variables (r=-0.370, p=0.048). These findings support the assumed role of GDNF in the regulation of IGD.
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