Blood Res.  2018 Jun;53(2):163-166. 10.5045/br.2018.53.2.163.

The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult

• Xie Y
• Visconte V
• Duan L
• Rogers HJ

• KMID: 2451036
• DOI: http://doi.org/10.5045/br.2018.53.2.163

Abstract

No abstract available.

MeSH Terms

Animals
Babesiosis*
Diagnosis*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Young Adult*

Figure

• 

  Fig. 1 Bone marrow (BM) histopathologic and cytogenetic findings at diagnosis. (A, B) BM aspirate and biopsy showed left-shifted granulocytic hyperplasia with a high myeloid:erythroid ratio and megakaryocytes with small hypolobated (dwarf) forms (A: Wright-Giemsa stain, ×1,000, B: hematoxylin and eosin stain, ×400). (C) The composite pictures from the aspirate smears showed small single or multiple ring-form organisms within the erythrocytes. One of the erythrocytes in the left lower part showed the stage occurring after the breakdown of the classic tetrad (“Maltese cross”) (Wright-Giemsa stain, ×1,000). (D) Fluorescent in-situ hybridization in BM specimen using tri-color dual fusion probes (BCR/ABL1/ASS1) demonstrated BCR/ABL1 translocation (red-green fusion) in 3 interphase cells. ABL1 and ASS1 probes in chromosome 9q34 region and BCR probe in chromosome 22q11.2 region showed red, aqua, and green signals, respectively (Abbott Molecular, Abbott Park, IL).

Reference

1. Martinot M, Zadeh MM, Hansmann Y, et al. Babesiosis in immunocompetent patients, Europe. Emerg Infect Dis. 2011; 17:114–116. PMID: 21192869.

2. Vannier EG, Diuk-Wasser MA, Ben Mamoun C, Krause PJ. Babesiosis. Infect Dis Clin North Am. 2015; 29:357–370. PMID: 25999229.

3. Akel T, Mobarakai N. Hematologic manifestations of babesiosis. Ann Clin Microbiol Antimicrob. 2017; 16:6. PMID: 28202022.

4. Lubin AS, Snydman DR, Miller KB. Persistent babesiosis in a stem cell transplant recipient. Leuk Res. 2011; 35:e77–e78. PMID: 21185598.

5. Chiang E, Haller N. Babesiosis: an emerging infectious disease that can affect those who travel to the northeastern United States. Travel Med Infect Dis. 2011; 9:238–242. PMID: 21862413.

6. Yager PH, Luginbuhl LM, Dekker JP. Case records of the Massachusetts General Hospital. Case 6-2014. A 35-day-old boy with fever, vomiting, mottled skin, and severe anemia. N Engl J Med. 2014; 370:753–762. PMID: 24552323.

7. de Ramón C, Cid J, Rodríguez-Tajes S, et al. Severe Severe Babesia microti infection in an American immunocompetent patient diagnosed in Spain. Transfus Apher Sci. 2016; 55:243–244. PMID: 27499182.

8. Castagnetti F, Gugliotta G, Baccarani M, et al. Differences among young adults, adults and elderly chronic myeloid leukemia patients. Ann Oncol. 2015; 26:185–192. PMID: 25361995.

9. Pemmaraju N, Kantarjian H, Shan J, et al. Analysis of outcomes in adolescents and young adults with chronic myelogenous leukemia treated with upfront tyrosine kinase inhibitor therapy. Haematologica. 2012; 97:1029–1035. PMID: 22271898.

10. Sakurai M, Mori T, Karigane D, et al. Unfavorable outcome of chronic myelogenous leukemia in adolescent and young adults treated with tyrosine kinase inhibitors. Int J Hematol. 2015; 102:342–348. PMID: 26187695.