Ann Lab Med.  2017 Jul;37(4):336-338. 10.3343/alm.2017.37.4.336.

A Case of Acute Myeloid Leukemia Concurrent With Untreated Chronic Lymphocytic Leukemia

• Lee HY
• Park CJ
• You E
• Cho YU
• Jang S
• Seo EJ

• KMID: 2376792
• DOI: http://doi.org/10.3343/alm.2017.37.4.336

Abstract

No abstract available.

MeSH Terms

Leukemia, Lymphocytic, Chronic, B-Cell*
Leukemia, Myeloid, Acute*

Figure

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  Fig. 1 Coexistence of myeloblasts and neoplastic lymphoid cells on bone marrow aspirate smear (Wright stain, ×1,000).

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  Fig. 2 Flow cytometric immunophenotyping and chromosomal analysis with bone marrow aspirate. (A-a) Gating for the two populations of neoplastic cells (myeloblasts of AML and mature lymphoid cells of CLL); (A-b) Myeloblasts with co-expression of CD34 and CD117; (A-c) Mature B-lymphoid cells with co-expression of CD19 and CD5; (A-d) Mature B-lymphoid cells with co-expression of CD19 and CD23.(B) Abnormal karyotype with del(13q) and add(14q).(C) FISH findings with each probe. (C-a) Terminal deletion of 13q34 with the D13S319/13qter Dual Color Probe (Cytocell, Cambridge, UK); (C-b) IGH deletion on 14q32 with the LSI IGH Dual Color Probe (Vysis, Downers Grove, IL, USA). Abbreviations: SSC, Side Scatter; CD, cluster of differentiation.

Reference

1. Lai R, Arber DA, Brynes RK, Chan O, Chang KL. Untreated chronic lymphocytic leukemia concurrent with or followed by acute myelogenous leukemia or myelodysplastic syndrome. A report of five cases and review of the literature. Am J Clin Pathol. 1999; 111:373–378.

2. Muta T, Okamura T, Niho Y. Acute myelogenous leukemia concurrent with untreated chronic lymphocytic leukemia. Int J Hematol. 2002; 75:187–190.

3. Stern N, Shemesh J, Ramot B. Chronic lymphatic leukemia terminating in acute myeloid leukemia: review of the literature. Cancer. 1981; 47:1849–1851.

4. Conlan MG, Mosher DF. Concomitant chronic lymphocytic leukemia, acute myeloid leukemia, and thrombosis with protein C deficiency. Case report and review of the literature. Cancer. 1989; 63:1398–1401.

5. Lima M, Porto B, Rodrigues M, Teixeira MA, Coutinho J, Ribeiro AC, et al. Cytogenetic findings in a patient presenting simultaneously with chronic lymphocytic leukemia and acute myeloid leukemia. Cancer Genet Cytogenet. 1996; 87:38–40.

6. Gottardi M, Gattei V, Degan M, Bomben R, Zucchetto A, Tecchio C, et al. Concomitant chronic lymphocytic leukemia and acute myeloid leukemia: evidence of simultaneous expansion of two independent clones. Leuk Lymphoma. 2006; 47:885–889.

7. Graf T. Differentiation plasticity of hematopoietic cells. Blood. 2002; 99:3089–3101.

8. Hou YH, Srour EF, Ramsey H, Dahl R, Broxmeyer HE, Hromas R. Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4. Blood. 2005; 105:3488–3492.