Korean J Pancreas Biliary Tract.  2018 Oct;23(4):182-189. 10.15279/kpba.2018.23.4.182.

Intracystic Papillary Neoplasm of the Gallbladder Arising from a Localized Adenomyomatous Hyperplasia

  • 1Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Korea.
  • 2Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Korea.
  • 3Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. 4unii@hanmail.net


Adenomyomatous hyperplasia (AMH) of the gallbladder commonly accompanies chronic cholecystitis and may be classified into three types according to the gross features: segmental, localized (fundal), and diffuse types. In situ or invasive carcinomas arising from and confined to AMH are rarely observed, especially of the segmental type. Intracystic papillary neoplasm (IPN) is one of the precancerous lesions of the gallbladder. IPN usually grows into the lumen and produces a polypoid or papillary mass. Here, we report an extremely rare case of IPN arising from and limited to a localized AMH incidentally detected in a brain-dead 68-year-old female patient during organ harvesting.


Adenomyomatous hyperplasia; Adenomyomatosis; Papillary neoplasm; Gallbladder
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