Nat Prod Sci.  2019 Mar;25(1):72-75. 10.20307/nps.2019.25.1.72.

Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells

Affiliations
  • 1College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
  • 2College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, South Korea. s1004jh@gmail.com, gyoon@mokpo.ac.kr
  • 3KIST Gangneung Institute, Gangneung 25451, Republic of Korea.
  • 4College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea.

Abstract

Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with ICâ‚…â‚€ values of 9.15 and 13.95 µM, respectively.

Keyword

Asarum sieboldii; Cytotoxicity; Breast cancer; Xanthoxylol
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