Nat Prod Sci.  2019 Mar;25(1):72-75. 10.20307/nps.2019.25.1.72.

Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells

• Kim E
• Kim HJ
• Oh HN
• Kwak AW
• Kim SN
• Kang BY
• Cho SS
• Shim JH
• Yoon G

• KMID: 2443107
• DOI: http://doi.org/10.20307/nps.2019.25.1.72

Abstract

Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with ICâ‚…â‚€ values of 9.15 and 13.95 µM, respectively.

Keyword

Asarum sieboldii; Cytotoxicity; Breast cancer; Xanthoxylol

MeSH Terms

Asarum*
Breast Neoplasms*
Breast*
Humans*
In Vitro Techniques

Figure

• 

  Fig. 1. Structures of isolated compounds (1–6) from A. sieboldii.

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