Nat Prod Sci.  2019 Mar;25(1):34-37. 10.20307/nps.2019.25.1.34.

Isolation of Constituents with Nitric Oxide Synthase Inhibition Activity from Phryma leptostachya var. asiatica

  • 1College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • 2College of Oriental Medicine, Sangji University, Wonju 26339, Korea.
  • 3Department of Pharmaceutical Engineering, Sangji University, Wonju 26339, Korea.


Phytochemical studies were performed to identify the active principles of Phryma leptostachya var. asiatica (Phyrymaceae) for anti-inflammation. The anti-inflammatory activity was assessed by measuring the inhibition rate on nitric oxide (NO) formation in lipopolysaccharide (LPS)-activated macrophage 264.7 cells. Of the five compounds including ursolic acid, phrymarolin I, harpagide, haedoxancoside A, and acteoside isolated from this plant, ursolic acid showed the most prominent inhibition of NO formation. Therefore, ursolic acid may be the anti-inflammatory principle of Phryma leptostachya var. asiatica.


Phryma leptostachya var. asiatica; Phyrymaceae; nitric oxide; anti-inflammatory; ursolic acid
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