Korean J Dermatol.  2019 Feb;57(2):94-96. 10.0000/kjd.2019.57.2.94.

Vitiligo with Leukotrichia Following Topical Diphenylcyclopropenone Immunotherapy for Acute Diffuse and Total Alopecia

  • 1Department of Dermatology, Kosin University College of Medicine, Busan, Korea. ksderm77@unitel.co.kr
  • 2Department of Dermatology, Kyung Hee University College of Medicine, Seoul, Korea.


Leukotrichia is defined as depigmentation of hair within vitiligo macules and is considered indicative of the destruction of the melanocyte reservoir within the hair follicle. A 15-year-old woman with acute diffuse and total alopecia (ADTA) presented with white hair growth with vitiligo on the right half of the scalp after 6 cycles of diphenylcyclopropenone (DPCP) application for ADTA. At the start of treatment, black hair growth was observed on the untreated, left half of the scalp. Seven months later, sustained growth of white hair on the right side of scalp was observed without further treatment. A diagnosis of vitiligo with leukotrichia following DPCP immunotherapy was made. She was treated with narrowband ultraviolet B (NBUVB) phototherapy three times per week. The vitiligo lesion with leukotrichia disappeared almost completely after 82 sessions of NBUVB phototherapy over 18 months. Herein, we report a 15-year-old woman with ADTA who developed vitiligo with leukotrichia following topical DPCP immunotherapy.


Diphenylcyclopropenone; Narrowband ultraviolet B phototherapy; Vitiligo; Leukotrichia
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