J Korean Ophthalmol Soc.  2019 Mar;60(3):239-245. 10.3341/jkos.2019.60.3.239.

Comparison of Efficacy and Sensation of Instillation between 0.05% Cyclosporine Nanoemulsion and Microemulsion Type

Affiliations
  • 1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. taeyoung15.chung@samsung.com
  • 2Department of Preventive Medicine, Graduate School, The Catholic University of Korea, Seoul, Korea.

Abstract

PURPOSE
To evaluate and compare the efficacy and sensation of instillation between 0.05% cyclosporine nanoemulsion group and microemulsion group.
METHODS
This is a double-blind, prospective randomized clinical trial. Patients had 2 weeks of wash-out period before the study. They were randomly assigned to either nanoemulsion group or microemulsion group and treated with each group's cyclosporine eye drop. Artificial eye drop and topical steroid were used together according to severity of dryness of cornea. We checked every patient's Break-up time (BUT), Schirmer test, Staining Score and Ocular surface disease index (OSDI) on baseline, 1 month and 3 months after. Patients also self-checked frequency of use of artificial eye drop and topical steroid. Sensation of instillation was also checked.
RESULTS
Both nanoemulsion eye-drop and microemulsion eye-drop improved BUT, Schirmer test, Staining Score and OSDI throughout 12 weeks. The nanoemulsion type reduced OSDI significantly compared to the microemulsion type. The mean frequency of use of artificial tear and topical steroid was similar in both groups. Foreign body sense score was higher in microemulsion group.
CONCLUSIONS
0.05% cyclosporine nanoemulsion type has simillar efficacy and subjectively less foreign body sensation.

Keyword

Cyclosporine; Dry eye syndromes; Microemulsion; Nanoemulsion

MeSH Terms

Cornea
Cyclosporine*
Dry Eye Syndromes
Eye, Artificial
Foreign Bodies
Humans
Prospective Studies
Sensation*
Tears
Cyclosporine

Figure

  • Figure 1. Comparison of OSDI between Nanoemulsion and Microemulsion group. Values are presented as mean ± standard deviation unless otherwise indicated. OSDI = ocular surface disease index; RM ANOVA = repeated-measured analysis of variance.

  • Figure 2. Comparison of sensation of instillation between nanoemulsion and microemulsion group. Values are presented as mean ± standard deviation unless otherwise indicated. There was no statistically significant difference between 2 gruops by Independent t-test. Mo = months.


Reference

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