Korean J Pediatr Infect Dis.  2005 Nov;12(2):101-107. 10.14776/kjpid.2005.12.2.101.

C-reactive Protein Level in a Variety of Infectious Diseases

Affiliations
  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. leekyungyil@catholic.ac.kr

Abstract

PURPOSE
We evaluated the C-reactive protein(CRP), white blood cell(WBC) and neutrophil levels in the various infectious diseases in a single hospital.
METHODS
A total of 640 medical records of children with infectious diseases such as bacterial meningitis(19 cases), acute pyelonephritis(55 cases), measles(253 cases), chicken pox (38 cases), mycoplasma pneumonia(160 cases), tsutsugamushi disease(39 cases) and Kawasaki disease(152 cases) admitted to The Catholic University of Korea, Daejeon St. Mary's hospital from 1996 to 2002 were retrospectively analyzed.
RESULTS
The mean CRP level was 17.9±6.4 mg/dL in bacterial meningitis, 9.1±5.6 mg/dL in Kawasaki disease, and 8.1±3.3 mg/dL in acute pyelonephritis. In the mycoplasma pneumonia and tsutsugamush disease group(atypical bacterial group), the CRP level was 3.2±2.5 mg/dL, and 1.0±0.8 mg/dL in the viral diseases group(measles and chicken pox). There were also significant differences for the WBC count and neutrophil differential between the 3 infectious groups with higher level in the bacterial infections group(15,600±6,100/mm³, 62±21%) than in the atypical bacterial infections and in the viral infections group(9,600±3,300 mm³, 57±11% and 7,300±2,900/mm³, 49±16%, respectively). The inflammatory indices in Kawasaki disease were like those of bacterial infections. There was a correlation between CRP level and WBC or neutrophil count in the bacterial infections and Kawasaki disease groups.
CONCLUSION
The CRP, WBC and neutrophil levels showed a clear difference between the infectious diseases according to causative agents. The WBC and neutrophil level was different according to age in measles and mycoplasma pneumonia. There was a correlation between CRP level and WBC or neutrophil count in the bacterial infections and Kawasaki disease groups.

Keyword

C-reactive protein; White blood cell; Neutrophil; Tsutsugamushi disease; Mycoplasma; Infection

MeSH Terms

Bacterial Infections
C-Reactive Protein*
Chickenpox
Chickens
Child
Communicable Diseases*
Humans
Korea
Leukocytes
Measles
Medical Records
Meningitis, Bacterial
Mucocutaneous Lymph Node Syndrome
Mycoplasma
Neutrophils
Pneumonia, Mycoplasma
Pyelonephritis
Retrospective Studies
Scrub Typhus
Virus Diseases
C-Reactive Protein
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