Korean J Pediatr Infect Dis.  2007 Nov;14(2):194-198. 10.14776/kjpid.2007.14.2.194.

A case of PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome

Affiliations
  • 1Depatrment of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea. sunghocha@khu.ac.kr

Abstract

The PFAPA syndrome is characterized by periodic fever, malaise, aphthous stomatitis, pharyngitis and cervical lymphadenitis without long-term sequelae. It has been known as one of the cause of periodic fever in children. Because there is no specific laboratory findings, the diagnosis of PFAPA syndrome is not only made by exclusion of diseases which are related to the other causes of periodic fever, but also made by a careful history and characteristic clinical manifestations. The dramatic response to the single oral dose of corticosteroid is unique to this syndrome. The PFAPA syndrome tends to be resolved without any long-term adverse sequelae. We have reported a 3 year old boy who was diagnosed as having PFAPA syndrome by episodes of periodic fever for 3 months and by excluding other febrile diseases. He was treated with oral prednisolone and his symptoms had been improved dramatically.

Keyword

Periodic fever; PFAPA syndrome; Fever of unknown origin

MeSH Terms

Child
Diagnosis
Fever of Unknown Origin
Fever*
Humans
Lymphadenitis
Male
Pharyngitis*
Prednisolone
Stomatitis, Aphthous*
Prednisolone

Cited by  1 articles

Clinical Manifestations of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome from a Single Center
Minsoo Shin, Eun Hwa Choi, Mi Seon Han
Pediatr Infect Vaccine. 2019;26(3):179-187.    doi: 10.14776/piv.2019.26.e20.

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