Korean J Otorhinolaryngol-Head Neck Surg.
2018 Jun;61(6):275-280. 10.3342/kjorl-hns.2018.00346.
Vocal Fold Regeneration: Current Review
- Affiliations
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- 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital, Daejeon, Korea. drchoung@catholic.ac.kr
- KMID: 2436468
- DOI: http://doi.org/10.3342/kjorl-hns.2018.00346
Abstract
- The extracellular matrix (ECM) of the vocal folds cannot be replaced after severe injury, but heal as scars. Scarred vocal folds cause voice problems. Many treatments have been attempted for vocal fold scarring, but their effectiveness is limited because the ECM composition does not normalize. Therefore, until now the prevention of scar formation has been important. In the field of regenerative medicine, cell therapies such as stem cell transplantation, and the implantation of several types of growth factors with or without scaffolds have been used. In this article, we reviewed the published research related to vocal fold regeneration and tried to think about the limitations of current studies and the future direction of treatment.
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