Korean J Intern Med.
2012 Dec;27(4):426-435.
Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study
- Affiliations
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- 1Division of Pulmonary and Critical Care Medicine, Daegu Fatima Hospital, Daegu, Korea.
- 2Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
- 3Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
- 4Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. ghlee@med.yu.ac.kr
- 5Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea.
- 6Department of Internal Medicine, Sunlin Hospital, Handong Global University, Pohang, Korea.
Abstract
- BACKGROUND/AIMS
Patients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning activities in patients with severe airflow limitation.
METHODS
Data of 133 patients with severe airflow limitation were analyzed in a prospective, non-interventional study. A clinical symptom questionnaire was completed by patients at baseline. In patients having morning symptoms, defined by at least one or more prominent or aggravating symptom during morning activities, a morning activity questionnaire was also completed at baseline and following 2 months of COPD treatment.
RESULTS
The most frequently reported COPD symptom was breathlessness (90.8%). Morning symptoms were reported in 76 (57%) patients; these had more frequent and severe clinical COPD symptoms. The most frequently reported morning activity was getting out of bed (82.9%). The long acting muscarinic antagonist (odds ratio [OR], 6.971; 95% confidence interval [CI], 1.317 to 11.905) and chest tightness (OR, 0.075; 95% CI, 0.011 to 0.518) were identified as significantly related to absence of morning symptoms. There was no significant correlation between the degree of forced expiratory volume in 1 second improvement and severity score differences of all items of morning activity after 2-month treatment.
CONCLUSIONS
Fifty-seven percent of COPD patients with severe airflow limitation have morning symptoms that limit their morning activities. These patients also have more prevalent and severe COPD symptoms. The results of this study therefore provide valuable information for the development of patient-reported outcomes in COPD.
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