Mood Emot.  2018 Jul;16(2):69-76. 10.0000/me.2018.16.2.69.

Korean Medication Algorithm for Bipolar Disorder 2018 : Mixed Features

Affiliations
  • 1Department of Psychiatry, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
  • 2Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. wmbahk@catholic.ac.kr
  • 3Department of Psychiatry, Naju National Hospital, Naju, Korea.
  • 4Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, Korea. cogni@naver.com
  • 5Department of Psychiatry, School of Medicine, Konkuk University, Chungju, Korea.
  • 6Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University and Paik Institute for Clinical Research, Busan, Korea.
  • 7Department of Health Science and Technology, Graduate School of Inje University, Busan, Korea.
  • 8Department of Psychiatry, Jeju National University Hospital, Jeju, Korea.
  • 9Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, Korea.
  • 10Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, Korea.
  • 11Department of Psychiatry, Myongji Hospital, Goyang, Korea.
  • 12Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, Korea.

Abstract


OBJECTIVES
The Korean Medication Algorithm for Bipolar Disorder 2018 (KMAP-BP 2018) has been revised again as a result of a consensus of opinions among experts. The mixed episode was changed to mixed features in DSM-5. In this study, we will describe the preference and recommendation of KMAP-BP 2018 for the treatment of mood episodes with mixed features.
METHODS
Out of 84 members of the review committee, 61 completed the survey. We analyzed the answers, discussed the data, and held a clinician hearing.
RESULTS
The preferred first-step strategies for mixed features with more manic symptoms were a combination of mood stabilizers (MS), atypical antipsychotics (AAP), and AAP monotherapy. For mixed features with more depressive symptoms, a combination of MS and lamotrigine (LTG), a combination of MS and AAP, and a combination of AAP and LTG were preferred. For mixed features with manic and depressive symptoms, a combination of MS and AAP, and AAP monotherapy were preferred.
CONCLUSION
For mixed features, a combination of MS and AAP was generally preferred, and lamotrigine was preferred for depressive symptoms. We hope this KMAP-BP 2018 to be helpful for clinicians that treat patients with bipolar disorder in Korea.

Keyword

Bipolar disorder; KMAP-BP 2018; Mixed features
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