Ann Dermatol.  2016 Feb;28(1):115-116. 10.5021/ad.2016.28.1.115.

Increasing Numbers of Mast Cells in Skin Lesions of Hyperpigmented Mycosis Fungoides with Large-Cell Transformation

• Kondo M
• Igawa K
• Munetsugu
• Shibama S
• Nishizawa
• Tokoro S
• Yokozeki H

• KMID: 2429494
• DOI: http://doi.org/10.5021/ad.2016.28.1.115

Abstract

No abstract available.

MeSH Terms

Mast Cells*
Mycosis Fungoides*
Skin*

Figure

• 

  Fig. 1 (A) Clinical manifestation. Hyperpigmented plaques on the trunk. (B) Histology of the lesional skin of a hyperpigmented plaque. Slight acanthosis with atypical lymphocytic infiltration within the epidermis and upper dermis, containing abundant melanophages (H&E, ×100). (C, D) Immunohistochemical analysis (×100). (C) CD4 staining and (D) CD8 staining. (E) Mast cells in lesional skin. Red arrowheads indicate mast cells (toluidine blue, ×400).

Reference

1. Yamamoto T, Katayama I, Nishioka K. Role of mast cell and stem cell factor in hyperpigmented mycosis fungoides. Blood. 1997; 90:1338–1340.

2. Lee JS, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC. A case of hyperpigmented mycosis fungoides: a rare variant. J Eur Acad Dermatol Venereol. 2007; 21:983–985.

3. Erbil H, Sezer E, Koseoglu D, Filiz N, Kurumlu Z, Bülent Taştan H, et al. Hyperpigmented mycosis fungoides: a case report. J Eur Acad Dermatol Venereol. 2007; 21:982–983.

4. Pavlovsky L, Mimouni D, Amitay-Laish I, Feinmesser M, David M, Hodak E. Hyperpigmented mycosis fungoides: an unusual variant of cutaneous T-cell lymphoma with a frequent CD8+ phenotype. J Am Acad Dermatol. 2012; 67:69–75.