Korean J Dermatol.
2004 Mar;42(3):324-327.
A Case of Transformation of Mycosis Fungoides to Large Cell Lymphoma
- Affiliations
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- 1Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. eslee@smc.samsung.co.kr
- 2Department of Dermatology, Gachon Medical School, Inchon, Korea.
Abstract
- Cutaneous T cell lymphoma (mycosis fungoides/Sezary syndrome) is a clonal malignacy of helper (CD4+) T lymphocytes usually first detected in the skin. In 8-55% of mycosis fungoides, the malignant T cell clone undergoes, cytologic transformation characterized by pleomorphic, large cells with prominent nucleoli, resulting in the morphologic appearance of a large cell lymphoma. The prognosis of large cell transformation of mycosis fungoides is poor; so detection of cytologic transformation is important to decide further treatment. We report a case of 22-year-old mycosis fungoides patient who developed large cell transformation during photochemotherapy (PUVA).
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