J Pathol Transl Med.  2018 Nov;52(6):355-356. 10.4132/jptm.2018.09.07.

Alveolar Squamous Cell Metaplasia: Preneoplastic Lesion?

• Handra-Luca A

• KMID: 2427516
• DOI: http://doi.org/10.4132/jptm.2018.09.07

Abstract

No abstract available.

MeSH Terms

Epithelial Cells*
Metaplasia*

Figure

• 

  Fig. 1. (A) The lung parenchyma shows a zone of multiple (approximatively 10) p63-positive squamous cell metaplasia (SCM) foci (black arrows for SCM foci, white arrow for lymphocytic focus). (B) On the hematoxylin and eosin stained slide, the lesions consist in a multilayered epithelium composed of basal cuboidal cells, suprabasal cells and superficial spindle-appearing cells (black arrows). (C) The basal and suprabasal cells are immunoreactive for p63 while superficial cells are negative (black arrows for p63+ cells). (D) Thyroid transcription factor 1 is expressed by the cells throughout the entire thickness of the lesion, in both p63+ and p63– cells (black arrows for SCM foci, gray arrow for atypical pneumocyte nuclei). (E, F) A cystic cellular bud (reminiscent of thyroid solid cell nests) is detected in an alveolar septum (black arrows for the SCM bud, gray arrows for binucleated pneumocytes). (G) One of the SCM foci develop at close contact to the lymphocytic infiltrate (p63 immunohistochemistry, black arrow for the SCM focus, white arrow for the lymphcytic infiltrate). To note would be the presence of a binucleation with immunoreactivity to p63 in the SCM focus. (H) Cytokeratin 5/6 is expressed in spindle-appearing cells lining the alveoli and in the SCM foci (black arrows for cytokeratin 5/6+ cells).

Reference

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