Obstet Gynecol Sci.  2018 Sep;61(5):631-635. 10.5468/ogs.2018.61.5.631.

A rare case of squamous cell carcinoma in situ arising in mature cystic teratoma

• Kyeong HK
• Ku HR
• Kim CW
• Heo EJ

• KMID: 2426030
• DOI: http://doi.org/10.5468/ogs.2018.61.5.631

Abstract

Mature cystic teratoma (MCT) is the most common ovarian tumor. Secondary malignant tumors rarely arise in MCTs, and squamous cell carcinoma (SCC) is the most common form of such tumors. MCT-derived SCC in situ (CIS) is mostly found together with invasive SCC; it is seldom detected alone. A 44-year-old woman with breast cancer was found to have a left ovarian cyst (size > 8 cm) before treatment. She underwent bilateral salpingo-oophorectomy, and frozen biopsy showed MCT with focal proliferation of squamous epithelium and mild atypism. However, definitive pathologic diagnosis confirmed CIS arising in MCT. In addition, germline BRCA 1/2 test and human papillomavirus test of tumor tissue yielded negative results. This report is the first case of its kind in Korea. Our report can aid in clinical decision making and serve as a basis for follow-up studies on this rare type of CIS arising in MCT.

Keyword

Carcinoma in situ; Teratoma, mature; Malignant transformation; Germ cell tumor

MeSH Terms

Adult
Biopsy
Breast Neoplasms
Carcinoma in Situ
Carcinoma, Squamous Cell*
Clinical Decision-Making
Diagnosis
Epithelial Cells*
Epithelium
Female
Follow-Up Studies
Humans
Korea
Neoplasms, Germ Cell and Embryonal
Ovarian Cysts
Teratoma*

Figure

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  Fig. 1 (A) Abdominopelvic computed tomography scan showing an 8.5-cm well-defined bilocular mass composed of fat, fluid, and calcifications in the left adnexa. (B) Operative findings. (C) Atypical keratinocytes across the complete thickness of the skin. (D) Histopathologic image showing the high rate of proliferation of lesion cells.

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