Obstet Gynecol Sci.  2018 Sep;61(5):631-635. 10.5468/ogs.2018.61.5.631.

A rare case of squamous cell carcinoma in situ arising in mature cystic teratoma

  • 1Department of Obstetrics and Gynecology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicines, Changwon, Korea.
  • 2Department of Obstetrics and Gynecology, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea. 1109wls@naver.com


Mature cystic teratoma (MCT) is the most common ovarian tumor. Secondary malignant tumors rarely arise in MCTs, and squamous cell carcinoma (SCC) is the most common form of such tumors. MCT-derived SCC in situ (CIS) is mostly found together with invasive SCC; it is seldom detected alone. A 44-year-old woman with breast cancer was found to have a left ovarian cyst (size > 8 cm) before treatment. She underwent bilateral salpingo-oophorectomy, and frozen biopsy showed MCT with focal proliferation of squamous epithelium and mild atypism. However, definitive pathologic diagnosis confirmed CIS arising in MCT. In addition, germline BRCA 1/2 test and human papillomavirus test of tumor tissue yielded negative results. This report is the first case of its kind in Korea. Our report can aid in clinical decision making and serve as a basis for follow-up studies on this rare type of CIS arising in MCT.


Carcinoma in situ; Teratoma, mature; Malignant transformation; Germ cell tumor
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