Korean J Dermatol.  1997 Dec;35(6):1052-1058.

Immunohistochemical Study on Allergic Contact Dermatitis and Systemic Contact Dermatitis to Urushiol (Rhus verniciflua)

Affiliations
  • 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

BACKGROUND: The rhus has been known to be such a potent allergen that it causes severe contact dermatitis, and mary studies have tried to reveal the mechanism of allergic contact. dermatitis to urushiol. However, the mechanism of systemic contact dermatitis to urushiol is not, well-known, though the consumption of rhus as a health product and for desensitization is not unconmon in Korea.
OBJECTIVE
The purpose of this study was to evaluate the niechanism of systernic contact dermatis, and we carried out irnmunohistochemical stainings un the two strands of dermatitis (systemic arid,llergic contact dermatitis).
METHODS
The patients of systemir, contact dermatitis were divided into three groups by duration and severity of the illness according to the desired criteria. We perfor med immunohistor,hernical staining of the tissues from the patients with anti CD4, CD8, CDla, ICAM-1, IL-2R monoclorial antibodies.
RESULTS
1. The results were as follows. 1. The immunohistochemical staining showed that CD8 positive cell numbers in systemic contact dermatitis(18+/-10) were significantly lower than those of allergic contact der matitis(37 +/- 13) ( p<0.05). 2. The expressions of HLA-DR and ICAM-1 in the keratinocytes were not significantly different. between systemic and allergic contact derrnatitis(p>0.05).
CONCLUSION
The result suggest that lower numbers of CDH positive T cell in systemic contact dermatitis caused a reduation in the suppressor effect to the urushiol mediated immune rection and CD8 positive T cells play an important role in systemic contact dermatitis due to rhus.

Keyword

Immununohistochemical study; Systeniic contact dermatitis; Urushiol

MeSH Terms

Antibodies
Cell Count
Dermatitis
Dermatitis, Allergic Contact*
Dermatitis, Contact*
HLA-DR Antigens
Humans
Intercellular Adhesion Molecule-1
Keratinocytes
Korea
Rhus
T-Lymphocytes
United Nations
Antibodies
HLA-DR Antigens
Intercellular Adhesion Molecule-1
Full Text Links
  • KJD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr