Korean J Ophthalmol.  2018 Oct;32(5):382-390. 10.3341/kjo.2017.0129.

Effects of Choroidal Thickness on Refractive Outcome Following Cataract Surgery in Primary Angle Closure

• Song WK
• Sung KR
• Shin JW
• Kwon J

• KMID: 2422068
• DOI: http://doi.org/10.3341/kjo.2017.0129

Abstract

PURPOSE
To identify the preoperative biometric factors, including subfoveal choroidal thickness (CT), associated with refractive outcome after cataract surgery in eyes with primary angle closure (PAC).
METHODS
This study included 50 eyes of 50 PAC patients who underwent uneventful cataract surgery. Preoperatively, anterior segment parameters including anterior chamber depth (ACD) and lens vault were determined by anterior segment optical coherence tomography. Subfoveal CT was measured by spectral domain optical coherence tomography enhanced depth imaging before and at one month after surgery. Mean refractive error (MRE) was calculated as the difference in spherical equivalent between actual postoperative refraction determined one month postoperatively and that predicted using each of three IOL calculation formulas (SRK/II, SRK/T, and Haigis). Regression analyses were performed to investigate potential associations between MRE and putative factors.
RESULTS
Mean ACD was 1.9 ± 0.4 mm, and preoperative subfoveal CT was 250.8 ± 56.9 µm. The SRK/T (MRE, 0.199 ± 0.567 diopters [D]) and Haigis (MRE, 0.190 ± 0.727 D) formulas showed slight hyperopic shift, while the SRK/II formula demonstrated a myopic shift (MRE, −0.077 ± 0.623 D) compared with that expected after cataract surgery. Mean absolute refractive error was not significantly different between formulas. Higher preoperative lens vault and shallower ACD were associated with a hyperopic shift in all formulas, but not in a statistically significant manner. Thicker preoperative subfoveal choroid was associated with a myopic shift after cataract surgery in all formulas (SRK/II: β = −0.511, p < 0.001; SRK/T: β = −0.652, p < 0.001; Haigis: β = −0.671, p < 0.001). Greater postoperative reduction of subfoveal CT was associated with a myopic shift after cataract surgery in all formulas (SRK/II: β = −0.511, p < 0.001; SRK/T: β = −0.652, p < 0.001; Haigis: β = −0.671, p < 0.001).
CONCLUSIONS
Our results indicate that preoperative subfoveal CT and the difference between pre- and postoperative subfoveal CT are significant factors for predicting refractive error after cataract surgery in PAC patients. These findings should be considered when performing cataract surgery to optimize visual outcomes.

Keyword

Cataract surgery; Choroidal thickness; Lens vault; Primary angle closure; Refractive errors

MeSH Terms

Anterior Chamber
Cataract*
Choroid*
Humans
Refractive Errors
Tomography, Optical Coherence

Figure

• 

  Fig. 1 Choroidal thickness was measured at the subfovea and at 1 and 3 mm from the fovea superiorly, inferiorly, temporally, nasally by spectral-domain optical coherence tomography scan image. Mean choroidal thickness was (A) 243.4 µm before surgery and (B) 231.6 µm at one month after surgery. This eye showed a −0.75 diopters myopic shift compared with the expected refraction after cataract surgery.

• 

  Fig. 2 Scatterplots showing mean refractive error produced by (A) the SRK/II formula (r2 = 0.350, p ≤ 0.001, simple linear regression analysis); (B) the SRK/T formula (r2 = 0.502, p ≤ 0.001, simple linear regression analysis); and (C) the Haigis formula (r2 = 0.450, p ≤ 0.001, simple linear regression analysis) as measured with the IOLMaster Optical Biometer against subfoveal choroidal thickness. D = diopter.

• 

  Fig. 3 Scatterplots showing mean refractive error produced by (A) the SRK/II formula (r2 = 0.335, p = 0.019, simple linear regression analysis); (B) the SRK/T formula (r2 = 0.669, p ≤ 0.001, simple linear regression analysis); and (C) the Haigis formula (r2 = 0.384, p = 0.011, simple linear regression analysis) as measured with IOLMaster Optical Biometer against the difference between preoperative and postoperative subfoveal choroidal thickness. D = diopter.

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