J Gastric Cancer.  2018 Sep;18(3):305-312. 10.5230/jgc.2018.18.e26.

Long-term Survival after Repeated Local Therapy and Salvage Chemotherapy for Recurrent Metastases from Gastric Cancer: a Case Report and Literature Review

Affiliations
  • 1Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea. sook3529@hanmail.net
  • 2Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 3Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.
  • 4Department of Radiation Oncology, Chungbuk National University Hospital, Cheongju, Korea.
  • 5Department of Radiation Oncology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 6Department of Surgery, Chungbuk National University Hospital, Cheongju, Korea.
  • 7Department of Surgery, Chungbuk National University College of Medicine, Cheongju, Korea.

Abstract

We report a rare case of long-term survival in a patient who received local therapy and salvage chemotherapy for recurrent metastases, along with a literature review. A 65-year-old male patient underwent subtotal gastrectomy for advanced gastric adenocarcinoma. Six months after gastrectomy, 2 metastatic intra-abdominal lymph node enlargements were detected, which were treated with radiotherapy. At 55 months after gastrectomy, an abdominal wall mass was detected, which was treated by surgical resection. The patient received 5-fluorouracil/leucovorin/irinotecan chemotherapy for 27 months before and after radiotherapy and docetaxel chemotherapy for 6 months after surgical resection of the abdominal wall metastasis. At the last visit, 7.8 years since the initial resection of the primary gastric cancer and 6.2 years since detection of the first metastases, the patient was disease-free and required no further chemotherapy. This case suggests that repeated local therapy offers potential for long-term survival in a carefully selected subset of patients with recurrent metastases.

Keyword

Chemotherapy; Gastric cancer; Metastasis; Radiotherapy; Surgery
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