Cancer Res Treat.  2018 Jul;50(3):813-822. 10.4143/crt.2017.340.

Human Papillomavirus Genotype-Specific Persistence and Potential Risk Factors among Korean Women: Results from a 2-Year Follow-up Study

• Ingabire C
• Lim MK
• Won YJ
• Oh JK

• KMID: 2417870
• DOI: http://doi.org/10.4143/crt.2017.340

Abstract

PURPOSE
High-risk human papillomavirus (HPV) infection progression should be considered a critical factor for preventing cervical cancer, although most infections are transient and rarely persist. This study aimed to examine the specific types of HPV infections, their change patterns, and the potential risk factors among Korean women.
MATERIALS AND METHODS
We included 4,588 women who visited hospitals in Busan and Suwon for cervical cancer screening, and 1,224 of thesewomen attended a 2-yearfollow-up. Infection statuswas evaluated using HPV DNA testing (Hybrid Capture 2) and genotyping testing (Linear Array). Data regarding the potential risk factors for HPV infection were collected by trained nurses using structured questionnaires.
RESULTS
Among the 1,224 women (mean age, 47 years), 105 women (8.6%) were HPV-positive at baseline. HPV infections had been cleared among 92 women (87.6%) within 2 years. Only 13 infections (12.4%) were remained, and the 10 cases of them are high-risk HPV types including genotype 33, 45, 16, 35, and 52. Among women who were negative at baseline, the HPV incidence was 4.8%. The HPV incidence was marginally associated with having multiple sexual partners (odds ratio, 2.0; 95% confidence interval, 1.0 to 3.9), although it was not significantly associated with HPV persistence.
CONCLUSION
Most HPV infections (88%) among Korean women were cleared within 2 years, with only a small number of persistent infections. The persistent HPV genotypes were different in our study, compared to those from previous studies. Having multiple sexual partners was associated with acquiring a HPV infection, but not with persistence.

Keyword

Human papillomavirus; Genotype; Persistence; Clearance; Incidence

MeSH Terms

Busan
Female
Follow-Up Studies*
Genotype
Gyeonggi-do
Human Papillomavirus DNA Tests
Humans*
Incidence
Mass Screening
Risk Factors*
Sexual Partners
Uterine Cervical Neoplasms

Figure

• 

  Fig. 1. Participants in baseline and follow-up survey and their classification by the status of human papillomavirus (HPV) infection. LA, linear array.

Reference

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