J Periodontal Implant Sci.  2018 Jun;48(3):136-151. 10.5051/jpis.2018.48.3.136.

The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis

• Isler SC
• Unsal B
• Soysal F
• Ozcan G
• Peker E
• Karaca IR

• KMID: 2414927
• DOI: http://doi.org/10.5051/jpis.2018.48.3.136

Abstract

PURPOSE
The decontamination procedure is a challenging aspect of surgical regenerative therapy (SRT) of peri-implantitis that affects its success. The purpose of the present study was to determine the impact of additional topical gaseous ozone therapy on the decontamination of implant surfaces in SRT of peri-implantitis.
METHODS
A total of 41 patients (22 males, 19 females; mean age, 53.55±8.98 years) with moderate or advanced peri-implantitis were randomly allocated to the test group (ozone group) with the use of sterile saline with additional ozone therapy or the control group with sterile saline alone for decontamination of the implant surfaces in SRT of peri-implantitis. Clinical and radiographic outcomes were evaluated over a period of 12 months.
RESULTS
At the 12-month follow-up, the plaque and gingival index values were significantly better in the ozone group (P < 0.05). Probing depth decreased from 6.27±1.42 mm and 5.73±1.11 mm at baseline to 2.75±0.7 mm and 3.34±0.85 mm at the end of the 12-month observation period in the ozone and control groups, respectively. Similarly, the clinical attachment level values changed from 6.39±1.23 mm and 5.89±1.23 mm at baseline to 3.23±1.24 mm and 3.91±1.36 mm at the 12-month follow-up in the ozone and control groups, respectively. According to the radiographic evidence, the defect fill between baseline and 12 months postoperatively was 2.32±1.28 mm in the ozone group and 1.17±0.77 mm in the control group, which was a statistically significant between-group difference (P < 0.05).
CONCLUSIONS
Implant surface decontamination with the additional use of ozone therapy in SRT of peri-implantitis showed clinically and radiographically significant. Trial registry at ClinicalTrials.gov, NCT03018795.

Keyword

Decontamination; Heterografts; Ozone; Peri-implantitis

MeSH Terms

Decontamination
Female
Follow-Up Studies
Heterografts
Humans
Male
Ozone*
Peri-Implantitis*
Periodontal Index
Ozone

Figure

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  Figure 1 Flow chart of the study participants.

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  Figure 2 Preparation of CGF. (A) Centrifugation of blood samples with a CGF centrifuge machine. (B) Prepared CGF. (C) Red corpuscles were separated from fibrin clot. (D) Pieces of CGF. (E) CGF barrier membrane. (F) Xenograft mixed with CGF. CGF: concentrated growth factors.

• 

  Figure 3 Preoperative and postoperative clinical and radiographic views of the control group. (A) Radiographic peri-implant bone defect at baseline. (B) Probing of peri-implantitis site at baseline. (C) Clinical defect configuration after flap elevation. (D) Peri-implant bone defects were filled with a bovine-derived xenograft in combination with concentrated growth factor membranes. (E) Clinical view at 12 months postoperatively. (F) Defect fill at 12 months postoperatively.

• 

  Figure 4 Preoperative and postoperative clinical and radiographic views of the ozone group. (A) Radiographic view of the peri-implant bone defect at baseline. (B) Probing of peri-implantitis site at baseline. (C) Clinical defect configuration after flap elevation. (D) Implant surface decontamination using ozone therapy. (E) Clinical view at 12 months postoperatively. (F) Defect fill at 12 months postoperatively.

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