- The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy
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Hu L, Bai Z, Ma X, Bai N, Zhang Z
- KMID: 2471929
- J Gastric Cancer.
- 2020 Mar;20(1):95-105.
- doi: 10.5230/jgc.2020.20.e9
PURPOSE: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3... -
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- Establishment of a [¹â¸F]-FDG-PET/MRI Imaging Protocol for Gastric Cancer PDX as a Preclinical Research Tool
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Bae SW, Berlth F, Jeong KY, Suh YS, Kong SH, Lee HJ, Kim WH, Chung JK, Yang HK
- KMID: 2471926
- J Gastric Cancer.
- 2020 Mar;20(1):60-71.
- doi: 10.5230/jgc.2020.20.e7
PURPOSE: The utility of 18-fluordesoxyglucose positron emission tomography ([¹â¸F]-FDG-PET) combined with computer tomography or magnetic resonance imaging (MRI) in gastric cancer remains controversial and a rationale for patient selection is... -
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- Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma
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Na JC, Kim JH, Kim SY, Gu YR, Jun DY, Lee HH, Yoon YE, Choi KH, Hong SJ, Han WK
- KMID: 2471078
- Investig Clin Urol.
- 2020 Mar;61(2):216-223.
- doi: 10.4111/icu.2020.61.2.216
PURPOSE: Renal cell carcinoma is a heterogeneous kidney cancer, and over 403,000 cases were reported worldwide in 2018. Current methods for studying renal cell carcinoma are limited to two-dimensional (2D)... -
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- Involvement of the TNF-α Pathway in TKI Resistance and Suggestion of TNFR1 as a Predictive Biomarker for TKI Responsiveness in Clear Cell Renal Cell Carcinoma
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Hwang HS, Park YY, Shin SJ, Go H, Park JM, Yoon SY, Lee JL, Cho YM
- KMID: 2469348
- J Korean Med Sci.
- 2020 Feb;35(5):e31.
- doi: 10.3346/jkms.2020.35.e31
BACKGROUND: Mechanism and predictive biomarkers for tyrosine kinase inhibitor (TKI) resistance of advanced clear cell renal cell carcinoma (ccRCC) have not been fully evaluated. METHODS: We performed gene expression profiling on... -
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- Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
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Kang JH, Jang YS, Lee HJ, Lee CY, Shin DY, Oh SH
- KMID: 2470020
- Lab Anim Res.
- 2019 Dec;35(4):221-229.
- doi: 10.1186/s42826-019-0030-0
Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. For... -
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- Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
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Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B
- KMID: 2470017
- Lab Anim Res.
- 2019 Dec;35(4):194-201.
- doi: 10.1186/s42826-019-0028-7
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not... -
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- Macrophages in xenotransplantation
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Kim JY
- KMID: 2468157
- Korean J Transplant.
- 2019 Dec;33(4):74-82.
- doi: 10.4285/jkstn.2019.33.4.74
Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed... -
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- LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer
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Yang H, Peng M, Li Y, Zhu R, Li X, Qian Z
- KMID: 2466034
- J Gastric Cancer.
- 2019 Dec;19(4):460-472.
- doi: 10.5230/jgc.2019.19.e43
PURPOSE: Long noncoding RNA 00703 (LINC00703) was found originating from a region downstream of Kruppel-like factor 6 (KLF6) gene, having 2 binding sites for miR-181a. Since KLF6 has been reported... -
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- MiR-338-3p Enhances Ovarian Cancer Cell Sensitivity to Cisplatin by Downregulating WNT2B
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Niu Q, Liu Z, Gao J, Wang Q
- KMID: 2463793
- Yonsei Med J.
- 2019 Dec;60(12):1146-1156.
- doi: 10.3349/ymj.2019.60.12.1146
PURPOSE: Chemoresistance is a concern in ovarian cancer patients, in whom survival remains. MicroRNA, a novel class of small RNAs, have frequently been found to be dysregulated in human malignancies... -
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- Anti-cancer Activity of Paclitaxel, Lenvatinib and Radiation Combination Therapy on Anaplastic Thyroid Cancer in Vitro and in Vivo
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Jun S, Kim SY, Kim SM, Park KC, Kim HJ, Chang HJ, Lee YS, Chang HS, Park CS
- KMID: 2469230
- Korean J Head Neck Oncol.
- 2019 Nov;35(2):19-25.
- doi: 10.21593/kjhno/2019.35.2.19
BACKGROUND/OBJECTIVES: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at... -
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- Low Doses of Nonylphenol Promote Growth of Colon Cancer Cells through Activation of ERK1/2 via G Protein‒Coupled Receptor 30
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Xie M, Liang JL, Huang HD, Wang MJ, Zhang T, Yang XF
- KMID: 2460610
- Cancer Res Treat.
- 2019 Oct;51(4):1620-1631.
- doi: 10.4143/crt.2018.340
PURPOSE: Nonylphenol (NP) is an endocrine disruptor found in products such as cleaners, plastics, and detergents. It exerts actions similar to endogenous 17β-estradiol (E2) and is reported to influence various... -
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- Clinical Implementation of Precision Medicine in Gastric Cancer
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Jeon J, Cheong JH
- KMID: 2458826
- J Gastric Cancer.
- 2019 Sep;19(3):235-253.
- doi: 10.5230/jgc.2019.19.e25
Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinical treatment decisions are mostly made based on the extent of the tumor and its anatomy, such... -
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- Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiR-186-5p/MAP4K3 Axis in Hepatocellular Carcinoma
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Shan Y, Li P
- KMID: 2457480
- Yonsei Med J.
- 2019 Sep;60(9):842-853.
- doi: 10.3349/ymj.2019.60.9.842
PURPOSE: Long intergenic non-protein coding RNA 665 (LINC00665) plays a vital role in the development of cancer. Its function in hepatocellular carcinoma (HCC), however, remains largely unknown. MATERIALS AND METHODS: The... -
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- Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer
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Li LY, Kim HJ, Park SA, Lee SH, Kim LK, Lee JY, Kim S, Kim YT, Kim SW, Nam EJ
- KMID: 2454303
- Cancer Res Treat.
- 2019 Jul;51(3):1117-1127.
- doi: 10.4143/crt.2018.405
PURPOSE: Recurrence and chemoresistance (CR) are the leading causes of death in patients with high-grade serous carcinoma (HGSC) of the ovary. The aim of this study was to identify genetic... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors
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Daum S, Magnusson , Pes L, Garcia Fernandez J, Chercheja , Medda F, Nollmann F, Koester SD, Perez Galan P, Warnecke A, Abu Ajaj K, Kratz F
- KMID: 2450009
- Nucl Med Mol Imaging.
- 2019 Jun;53(3):189-198.
- doi: 10.1007/s13139-019-00587-w
PURPOSE: The purpose of this study was to investigate the albumin-binding compound 111In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors. METHODS: 111In-C4-DTPA was injected in... -
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- MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1
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Yang Q, Li J, Hu Y, Tang X, Yu L, Dong L, Chen D
- KMID: 2446954
- Yonsei Med J.
- 2019 Jun;60(6):500-508.
- doi: 10.3349/ymj.2019.60.6.500
PURPOSE: Lung adenocarcinoma (LA) is one of the major types of lung cancer. MicroRNAs (miRNAs) play an essential role in regulating responses of natural killer (NK) cells to cancer malignancy.... -
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- Dental alloplastic bone substitutes currently available in Korea
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Ku JK, Hong I, Lee BK, Yun PY, Lee JK
- KMID: 2467148
- J Korean Assoc Oral Maxillofac Surg.
- 2019 Apr;45(2):51-67.
- doi: 10.5125/jkaoms.2019.45.2.51
As dental implant surgery and bone grafts were widely operated in Korean dentist, many bone substitutes are commercially available, currently. For commercially used in Korea, all bone substitutes are firstly... -
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- A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
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Heo JR, Hwang KA, Kim SU, Choi KC
- KMID: 2464425
- Cancer Res Treat.
- 2019 Apr;51(2):797-811.
- doi: 10.4143/crt.2018.364
PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into... -
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- Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells
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Xu YY, Yu HR, Sun JY, Zhao Z, Li S, Zhang XF, Liao ZX, Cui MK, Li J, Li C, Zhang Q
- KMID: 2464405
- Cancer Res Treat.
- 2019 Apr;51(2):576-592.
- doi: 10.4143/crt.2018.100
PURPOSE: Although the interferon α (IFNα) signaling and the paired-like homeodomain transcription factor 2 (PITX2) have both been implicated in the progression of breast cancer (BCa), it remains obscure whether... -
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