Korean J Ophthalmol.  2018 Jun;32(3):211-220. 10.3341/kjo.2017.0105.

Factors Associated with Outcomes of Combined Phacoemulsification and Ahmed Glaucoma Valve Implantation

Affiliations
  • 1Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sungeye@gmail.com

Abstract

PURPOSE
To evaluate outcomes and factors associated with surgical failure in patients who underwent combined phacoemulsification and Ahmed glaucoma valve (AGV) implantation.
METHODS
This retrospective and longitudinal study enrolled 40 eyes (38 patients) that underwent combined phacoemulsification and AGV implantation. Visual acuity, intraocular pressure (IOP), and number of antiglaucoma medications were evaluated preoperatively and postoperatively. Complete success was defined as a last follow-up IOP of 6 to 21 mmHg without medication, qualified success as an IOP of 6 to 21 mmHg with medication, and failure as an IOP of >21 or <6 mmHg.
RESULTS
The mean follow-up period was 18 ± 10 months. Preoperative diagnoses were chronic angle closure glaucoma (35.0%), neovascular glaucoma (22.5%), uveitic glaucoma (17.5%), primary open-angle glaucoma (15.0%), and other (10.0%). IOP decreased from a mean of 30.5 ± 8.7 to 14.5 ± 3.7 mmHg at the last follow-up visit (p < 0.001). Treatment was classified as qualified success in 18 eyes (45%), complete success in 15 (37.5%), and failure in seven (17.5%). Twenty-two eyes (55%) showed improvement in visual acuity. The most common postoperative complication was a transient hypertensive phase (five eyes, 12.5%). Tube-iris touch was associated with surgical failure (hazard ratio, 8.615; p = 0.008).
CONCLUSIONS
Combined phacoemulsification and AGV implantation is an effective and safe surgical option for patients with refractory glaucoma and cataract. Postoperative tube-iris touch is an indicator of poor prognosis.

Keyword

Cataract; Glaucoma; Glaucoma drainage implants; Phacoemulsification

MeSH Terms

Cataract
Diagnosis
Follow-Up Studies
Glaucoma Drainage Implants
Glaucoma*
Glaucoma, Angle-Closure
Glaucoma, Neovascular
Glaucoma, Open-Angle
Humans
Intraocular Pressure
Longitudinal Studies
Phacoemulsification*
Postoperative Complications
Prognosis
Retrospective Studies
Visual Acuity

Figure

  • Fig. 1 Graph showing trends in mean intraocular pressure from preoperative to the last follow-up visit (error bars indicate 95% confidence intervals).

  • Fig. 2 Kaplan-Meier survival curve with 95% confidence intervals for the total number of eyes undergoing combined phacoemulsification and Ahmed valve implantation.

  • Fig. 3 Kaplan-Meier survival curves for eyes with and without postoperative tube-iris touch.


Reference

1. Quigley HA. Glaucoma. Lancet. 2011; 377:1367–1377. PMID: 21453963.
Article
2. Cook C, Foster P. Epidemiology of glaucoma: what's new? Can J Ophthalmol. 2012; 47:223–226. PMID: 22687296.
Article
3. Hoffman KB, Feldman RM, Budenz DL, et al. Combined cataract extraction and Baerveldt glaucoma drainage implant: indications and outcomes. Ophthalmology. 2002; 109:1916–1920. PMID: 12359614.
4. Pachimkul P, Intajak Y. Effect of lens extraction on primary angle closure in a Thai population. J Med Assoc Thai. 2008; 91:303–308. PMID: 18575281.
5. Thomas R, Walland M, Thomas A, Mengersen K. Lowering of intraocular pressure after phacoemulsification in primary open-angle and angle-closure glaucoma: a bayesian analysis. Asia Pac J Ophthalmol (Phila). 2016; 5:79–84. PMID: 26886123.
6. Traverso CE. Clear-lens extraction as a treatment for primary angle closure. Lancet. 2016; 388:1352–1354. PMID: 27707477.
Article
7. Zhang ZM, Niu Q, Nie Y, Zhang J. Reduction of intraocular pressure and improvement of vision after cataract surgeries in angle closure glaucoma with concomitant cataract patients. Int J Clin Exp Med. 2015; 8:16557–16563. PMID: 26629184.
8. Euswas A, Warrasak S. Intraocular pressure control following phacoemulsification in patients with chronic angle closure glaucoma. J Med Assoc Thai. 2005; 88(Suppl 9):S121–S125.
9. Zhuo YH, Wang M, Li Y, et al. Phacoemulsification treatment of subjects with acute primary angle closure and chronic primary angle-closure glaucoma. J Glaucoma. 2009; 18:646–651. PMID: 20010241.
Article
10. Tham CC, Kwong YY, Leung DY, et al. Phacoemulsification versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma with cataracts. Ophthalmology. 2009; 116:725–731. PMID: 19243831.
Article
11. Liu B, Guo DD, Du XJ, et al. Evaluation of Ex-PRESS implantation combined with phacoemulsification in primary angle-closure glaucoma. Medicine (Baltimore). 2016; 95:e4613. PMID: 27603352.
Article
12. Wang Y, Sheng Y, Wang M, Tao J. Management of different subtypes of primary angle closure with phacoemulsification and viscogoniosynechialysis. Semin Ophthalmol. 2017; 32:496–500. PMID: 27192389.
Article
13. Valenzuela F, Browne A, Srur M, et al. Combined phacoemulsification and Ahmed glaucoma drainage implant surgery for patients with refractory glaucoma and cataract. J Glaucoma. 2016; 25:162–166. PMID: 25264992.
Article
14. Chen DZ, Koh V, Sng C, et al. Complications and outcomes of primary phacotrabeculectomy with mitomycin C in a multi-ethnic asian population. PLoS One. 2015; 10:e0118852. PMID: 25775362.
Article
15. Gdih GA, Yuen D, Yan P, et al. Meta-analysis of 1- versus 2-site phacotrabeculectomy. Ophthalmology. 2011; 118:71–76. PMID: 20691480.
Article
16. Yassin SA. Bleb-related infection revisited: a literature review. Acta Ophthalmol. 2016; 94:122–134. PMID: 26249675.
Article
17. Nassiri N, Nassiri N, Sadeghi Yarandi S, et al. Combined phacoemulsification and Ahmed valve glaucoma drainage implant: a retrospective case series. Eur J Ophthalmol. 2008; 18:191–198. PMID: 18320510.
Article
18. Chung AN, Aung T, Wang JC, Chew PT. Surgical outcomes of combined phacoemulsification and glaucoma drainage implant surgery for Asian patients with refractory glaucoma with cataract. Am J Ophthalmol. 2004; 137:294–300. PMID: 14962420.
Article
19. Coleman AL, Mondino BJ, Wilson MR, Casey R. Clinical experience with the Ahmed glaucoma valve implant in eyes with prior or concurrent penetrating keratoplasties. Am J Ophthalmol. 1997; 123:54–61. PMID: 9186097.
Article
20. Kee C. Prevention of early postoperative hypotony by partial ligation of silicone tube in Ahmed glaucoma valve implantation. J Glaucoma. 2001; 10:466–469. PMID: 11740216.
Article
21. Krupin T, Ritch R, Camras CB, et al. A long Krupin-Denver valve implant attached to a 180 degrees scleral explant for glaucoma surgery. Ophthalmology. 1988; 95:1174–1180. PMID: 3211495.
22. Canto AP, Chhadva P, Cabot F, et al. Comparison of IOL power calculation methods and intraoperative wavefront aberrometer in eyes after refractive surgery. J Refract Surg. 2013; 29:484–489. PMID: 23820231.
Article
23. Fram NR, Masket S, Wang L. Comparison of intraoperative aberrometry, OCT-based IOL formula, Haigis-L, and Masket formulae for IOL power calculation after laser vision correction. Ophthalmology. 2015; 122:1096–1101. PMID: 25766733.
24. Nihalani BR, VanderVeen DK. Comparison of intraocular lens power calculation formulae in pediatric eyes. Ophthalmology. 2010; 117:1493–1499. PMID: 20466430.
Article
25. Waheed S, Ritterband DC, Greenfield DS, et al. Bleb-related ocular infection in children after trabeculectomy with mitomycin C. Ophthalmology. 1997; 104:2117–2120. PMID: 9400773.
Article
26. Yamamoto T, Kuwayama Y, Nomura E, et al. Changes in visual acuity and intra-ocular pressure following bleb-related infection: the Japan Glaucoma Society Survey of Bleb-related Infection Report 2. Acta Ophthalmol. 2013; 91:e420–e426. PMID: 23819592.
Article
27. Rockwood EJ, Parrish RK 2nd, Heuer DK, et al. Glaucoma filtering surgery with 5-fluorouracil. Ophthalmology. 1987; 94:1071–1078. PMID: 3684224.
Article
28. Englert JA, Freedman SF, Cox TA. The Ahmed valve in refractory pediatric glaucoma. Am J Ophthalmol. 1999; 127:34–42. PMID: 9932996.
Article
29. Gedde SJ, Panarelli JF, Banitt MR, Lee RK. Evidenced-based comparison of aqueous shunts. Curr Opin Ophthalmol. 2013; 24:87–95. PMID: 23287104.
Article
30. Fellenbaum PS, Almeida AR, Minckler DS, et al. Krupin disk implantation for complicated glaucomas. Ophthalmology. 1994; 101:1178–1182. PMID: 8035980.
Article
31. Lotufo DG. Postoperative complications and visual loss following Molteno implantation. Ophthalmic Surg. 1991; 22:650–656. PMID: 1792031.
Article
32. Melamed S, Cahane M, Gutman I, Blumenthal M. Postoperative complications after Molteno implant surgery. Am J Ophthalmol. 1991; 111:319–322. PMID: 2000901.
Article
33. Minckler DS, Heuer DK, Hasty B, et al. Clinical experience with the single-plate Molteno implant in complicated glaucomas. Ophthalmology. 1988; 95:1181–1188. PMID: 3211496.
Article
34. Benson SE, Mandal K, Bunce CV, Fraser SG. Is post-trabeculectomy hypotony a risk factor for subsequent failure? A case control study. BMC Ophthalmol. 2005; 5:7. PMID: 15811180.
Article
35. Won HJ, Sung KR. Hypertensive phase following silicone plate Ahmed glaucoma valve implantation. J Glaucoma. 2016; 25:e313–e317. PMID: 25774945.
Article
36. Law SK, Kornmann HL, Giaconi JA, et al. Early aqueous suppressant therapy on hypertensive phase following glaucoma drainage device procedure: a randomized prospective trial. J Glaucoma. 2016; 25:248–257. PMID: 25265004.
37. Pakravan M, Rad SS, Yazdani S, et al. Effect of early treatment with aqueous suppressants on Ahmed glaucoma valve implantation outcomes. Ophthalmology. 2014; 121:1693–1698. PMID: 24819857.
Article
38. Tzu JH, Shah CT, Galor A, et al. Refractive outcomes of combined cataract and glaucoma surgery. J Glaucoma. 2015; 24:161–164. PMID: 24247998.
Article
39. Burgoyne JK, WuDunn D, Lakhani V, Cantor LB. Outcomes of sequential tube shunts in complicated glaucoma. Ophthalmology. 2000; 107:309–314. PMID: 10690831.
Article
40. Coleman AL, Hill R, Wilson MR, et al. Initial clinical experience with the Ahmed glaucoma valve implant. Am J Ophthalmol. 1995; 120:23–31. PMID: 7611326.
Article
41. Gedde SJ, Schiffman JC, Feuer WJ, et al. Treatment outcomes in the tube versus trabeculectomy study after one year of follow-up. Am J Ophthalmol. 2007; 143:9–22. PMID: 17083910.
Article
42. Huang MC, Netland PA, Coleman AL, et al. Intermediate-term clinical experience with the Ahmed glaucoma valve implant. Am J Ophthalmol. 1999; 127:27–33. PMID: 9932995.
43. Ozdal PC, Vianna RN, Deschenes J. Ahmed valve implantation in glaucoma secondary to chronic uveitis. Eye (Lond). 2006; 20:178–183. PMID: 15761478.
44. Taglia DP, Perkins TW, Gangnon R, et al. Comparison of the Ahmed glaucoma valve, the Krupin eye valve with disk, and the double-plate Molteno implant. J Glaucoma. 2002; 11:347–353. PMID: 12169973.
Article
45. Wilson MR, Mendis U, Paliwal A, Haynatzka V. Long-term follow-up of primary glaucoma surgery with Ahmed glaucoma valve implant versus trabeculectomy. Am J Ophthalmol. 2003; 136:464–470. PMID: 12967799.
Article
46. Wilson MR, Mendis U, Smith SD, Paliwal A. Ahmed glaucoma valve implant vs trabeculectomy in the surgical treatment of glaucoma: a randomized clinical trial. Am J Ophthalmol. 2000; 130:267–273. PMID: 11020403.
Article
47. Ong C, Nongpiur M, Peter L, Perera SA. Combined approach to phacoemulsification and trabeculectomy results in less ideal refractive outcomes compared with the sequential approach. J Glaucoma. 2016; 25:e873–e878. PMID: 27483417.
Article
48. Hayashi K, Hayashi H, Nakao F, Hayashi F. Risk factors for corneal endothelial injury during phacoemulsification. J Cataract Refract Surg. 1996; 22:1079–1084. PMID: 8915805.
Article
49. Kohlhaas M, Klemm M, Kammann J, Richard G. Endothelial cell loss secondary to two different phacoemulsification techniques. Ophthalmic Surg Lasers. 1998; 29:890–895. PMID: 9824860.
Article
50. Nguyen QH, Budenz DL, Parrish RK 2nd. Complications of Baerveldt glaucoma drainage implants. Arch Ophthalmol. 1998; 116:571–575. PMID: 9596491.
Article
51. Zalloum JN, Ahuja RM, Shin D, Weiss JS. Assessment of corneal decompensation in eyes having undergone molteno shunt procedures compared to eyes having undergone trabeculectomy. CLAO J. 1999; 25:57–60. PMID: 10073639.
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