J Breast Cancer.  2015 Sep;18(3):291-295. 10.4048/jbc.2015.18.3.291.

Breast Cancer Arising Adjacent to an Involuting Fibroadenoma: Serial Changes in Radiologic Features

Affiliations
  • 1Department of Radiology, Breast Cancer Clinic, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. mines@yuhs.ac
  • 2Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Fibroadenoma is a common benign breast lesion and its malignant transformation is rare. There have been several case reports and studies that retrospectively reviewed breast cancers that arose within fibroadenomas; however, none of these studies reported serial changes in radiologic features of the cancer, including findings from mammography and ultrasound (US). We report a case of breast cancer arising adjacent to an involuting fibro adenoma in a 39-year-old woman who was undergoing serial follow-up after her fibroadenoma was diagnosed. Seven years after her diagnosis, the lesion showed evidence of coarse calcifications, a typical sign of involution. Four years later, US revealed a newly developed hypoechoic lesion with irregular margins and peripherally located calcifications adjacent to the fibroadenoma. A core biopsy was performed, and histopathological examination resulted in a diagnosis of invasive ductal carcinoma. When new suspicious features are observed in a fibroadenoma, radiologists should raise the concern for breast cancer and proceed with diagnosis and treatment accordingly.

Keyword

Breast neoplasms; Fibroadenoma; Magnetic resonance imaging; Mammography; Ultrasonography

MeSH Terms

Adenoma
Adult
Biopsy
Breast Neoplasms*
Breast*
Carcinoma, Ductal
Diagnosis
Female
Fibroadenoma*
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Mammography
Retrospective Studies
Ultrasonography
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