J Korean Med Assoc.  2018 Jan;61(1):57-61. 10.5124/jkma.2018.61.1.57.

Pharmacological treatment of chronic constipation: focused on oral laxatives

  • 1Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. dreun@dankook.ac.kr


Chronic constipation is a common functional gastrointestinal disorder that may have a significant impact on the quality of life of affected individuals. If dietary and lifestyle modifications are not successful, pharmacological interventions should be used to manage chronic constipation. The first-line conventional laxatives include bulk-forming, osmotic, and stimulant laxatives. If chronic constipation is refractory to conventional laxatives, prucalopride should be considered. The choice of a laxative should be made based on a consideration of the treatment duration, dosing schedule, type of agent, effects, and side effects of the agent, as well as cost-effectiveness. An individualized approach is needed according to the patient's underlying disease and clinical condition.


Constipation; Laxatives; Therapeutics

MeSH Terms

Appointments and Schedules
Gastrointestinal Diseases
Life Style
Quality of Life

Cited by  1 articles

Chronic Functional Constipation
Jeong Eun Shin, Kyung Sik Park, Kwangwoo Nam
Korean J Gastroenterol. 2019;73(2):92-98.    doi: 10.4166/kjg.2019.73.2.92.


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