J Korean Med Assoc.  2018 Jan;61(1):57-61. 10.5124/jkma.2018.61.1.57.

Pharmacological treatment of chronic constipation: focused on oral laxatives

• Shin JE

• KMID: 2405137
• DOI: http://doi.org/10.5124/jkma.2018.61.1.57

Abstract

Chronic constipation is a common functional gastrointestinal disorder that may have a significant impact on the quality of life of affected individuals. If dietary and lifestyle modifications are not successful, pharmacological interventions should be used to manage chronic constipation. The first-line conventional laxatives include bulk-forming, osmotic, and stimulant laxatives. If chronic constipation is refractory to conventional laxatives, prucalopride should be considered. The choice of a laxative should be made based on a consideration of the treatment duration, dosing schedule, type of agent, effects, and side effects of the agent, as well as cost-effectiveness. An individualized approach is needed according to the patient's underlying disease and clinical condition.

Keyword

Constipation; Laxatives; Therapeutics

MeSH Terms

Appointments and Schedules
Constipation*
Gastrointestinal Diseases
Laxatives*
Life Style
Quality of Life
Laxatives

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