Cancer Res Treat.  2015 Oct;47(4):949-953. 10.4143/crt.2014.052.

Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report

• Woo HS
• Lee KH
• Yoon PH
• Kim SJ
• Park I
• Kim YS
• Ahn HK
• Hong J
• Shin DB
• Sym SJ

• KMID: 2403417
• DOI: http://doi.org/10.4143/crt.2014.052

Abstract

Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.

Keyword

Oxaliplatin; Colorectal neoplasms; Thrombocytopenia; Neutropenia

MeSH Terms

Colonic Neoplasms
Colorectal Neoplasms
Female
Gingiva
Hemorrhage
Humans
Middle Aged
Neutropenia
Platinum
Purpura
Recurrence
Thrombocytopenia*
Platinum

Figure

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  Fig. 1. Acute bicytopenia on the sixth cycle of FOLFOX. WBC, white blood cell.

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  Fig. 2. Acute bicytopenia on the seventh cycle of FOLFOX. WBC, white blood cell.

Reference

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