Psychiatry Investig.
2017 Nov;14(6):876-878. 10.4306/pi.2017.14.6.876.
Polymorphism in the Promoter Region of SEMA5A Is Associated with Sociality Traits in Korean Subjects with Autism Spectrum Disorders
- Affiliations
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- 1Department of Pharmacology, School of Medicine, Eulji University, Daejeon, Republic of Korea. sakim@eulji.ac.kr
- 2Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
- 3Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Republic of Korea.
- 4Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Republic of Korea.
- 5Department of Psychiatry, Kyungpook National University Hospital, Daegu, Republic of Korea.
- 6Department of Preventive Medicine, School of Medicine, Eulji University, Daejeon, Republic of Korea.
- KMID: 2402417
- DOI: http://doi.org/10.4306/pi.2017.14.6.876
Abstract
- In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p < 0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.
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