J Korean Orthop Assoc.  2003 Aug;38(4):384-392.

Porous Beta-Calcium Pyrophosphate as a Bone Graft Substitute in a Canine Bone Defect Model

• Lee JH
• Lee DH
• Ha JH
• Ahn YJ
• Park JY
• Ryu HS
• Chang BS
• Hong KS
• Lee CK

Abstract

PURPOSE
To evaluate the possibility of using porous beta-calcium pyrophosphate (beta-CPP) as a bone graft substitute by comparing its osteoconduction and degradation with porous hydroxyapatite (HA). MATERIALS AND METHODS: Porous HA and porous beta-CPP were implanted in the proximal tibia of 7 dogs. Two animals were sacrificed at 8weeks and 5 animals were sacrificed at 20 weeks after surgery. Radiographs and histologic sections were evaluated. RESULTS: The mean period required for the radiolucent zone to disappear was 7.1+/-1.1 weeks in HA and 6.4+/-1.1 weeks in beta-CPP. By serial radiography, resorption was more prominent in porous beta-CPP than in porous HA at 8 weeks (p=0.04) and at 20 weeks. The proportion of bony tissue in the pore was 16.8% in HA and 29.7% in -CPP. The proportion of pores with bony tissue was 70.2% in HA and 62.5% in beta-CPP at 8 weeks. CONCLUSION: In beta-CPP, the new bone growth was as vigorous as in HA, but the degradation was more rapid than in HA. These results suggest that beta-CPP is a more ideal new bone graft substitute.

Keyword

Bone defect; Beta-calcium pyrophosphate; Hydroxyapatite; Bone graft substitute; Resorbability

MeSH Terms

Animals
Bone Development
Bone Regeneration
Dogs
Durapatite
Radiography
Tibia
Transplants*
Durapatite