Lab Med Online.  2018 Jan;8(1):1-6. 10.3343/lmo.2018.8.1.1.

Analytical Performance and Reference Interval of a Microfluidic Viscometer, Viscore-300 for the Measurement of Whole Blood Viscosity

  • 1Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, and Chonnam National University Medical School, Hwasun, Korea.
  • 2Environmental Health Center for Childhood Leukemia and Cancer, Chonnam National University Hwasun Hospital, and Chonnam National University Medical School, Hwasun, Korea.
  • 3College of Korean Medicine, Dongshin University, Naju, Korea.
  • 4School of Electronics and Computer Engineering, College of Engineering, Chonnam National University, Gwangju, Korea.


Whole blood viscosity (WBV) refers to the internal resistance that occurs when blood flows through blood vessels. WBV is known to be related to many diseases including cardiovascular and neurovascular diseases. We have investigated the analytical performance and established reference intervals for a newly developed microfluidic viscometer, Viscore-300 (NanoBiz, Korea), used for the measurement of WBV.
We performed a precision test of 240 measurements over 20 days using three control materials. For evaluation of repeatability, a total of 60 WBV measurements were made in 3 whole blood samples 20 times a day. A total of 100 whole blood samples were used to evaluate the accuracy of the Viscore-300 in comparison to a rotating viscometer, DV3T (Brookfield, USA), in accordance with the the Clinical and Laboratory Standards Institute's guidelines. To establish the reference intervals, 122 healthy individuals were enrolled in this study.
The precision and repeatability results showed that the CV was less than 5% for three samples and two shear rates. In the accuracy test, the mean differences between two viscometers were 0.09 cP (0.9%) and −0.07 cP (−1.4%) at shear rates of 10 s−1 and 300 s−1, respectively. The reference intervals of WBV for men were 6.88-13.52 cP at 10 s−1 and 4.32-6.43 cP at 300 s−1; those of women were 5.74-13.29 cP at 10 s−1 and 3.60-6.12 cP at 300 s−1.
Viscore-300 showed excellent precision and accuracy and it might be a good instrument for reporting WBV quickly and accurately.


Whole blood viscosity; Microfluidic viscometer; Viscore-300
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