Infect Chemother.  2013 Mar;45(1):94-98.

A Case of Meningococcal Sepsis and Meningitis with Complement 7 Deficiency in a Military Trainee

Affiliations
  • 1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
  • 2Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea. choekw@snu.ac.kr
  • 3Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.

Abstract

Complement component 7 (C7) deficiency leads to the loss of complement lytic function, and affected patients show increased susceptibility to encapsulated organisms infection, especially Neisseria meningitidis. Recently, we have experienced a 20-year-old military trainee with meningococcal sepsis and meningitis who was diagnosed as having C7 deficiency based upon the undetectable serum C7 protein on radioimmunoassay. This case emphasizes that although C7 deficiency is rare immune disorder, it is important to be aware of possibility about late complement deficiency among patients who present with meningococcal disease.

Keyword

Neisseria meningitidis; Complement 7 deficiency; Meningitis; Sepsis

MeSH Terms

Complement C7
Complement System Proteins
Humans
Immune System Diseases
Immunologic Deficiency Syndromes
Meningitis
Military Personnel
Neisseria meningitidis
Radioimmunoassay
Sepsis
Complement C7
Complement System Proteins
Immunologic Deficiency Syndromes
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