J Clin Neurol.  2017 Jul;13(3):312-314. 10.3988/jcn.2017.13.3.312.

Extra-Axial Mass in the Foramen Magnum Causing Cervical Compressive Myelopathy as a Complication of Rosai-Dorfman Disease

• Carrasco-García de León S
• Flores Barragán JM
• Relea Calatayud F
• Balcazar Rojas O

• KMID: 2391682
• DOI: http://doi.org/10.3988/jcn.2017.13.3.312

Abstract

No abstract available.

MeSH Terms

Foramen Magnum*
Histiocytosis, Sinus*
Spinal Cord Compression*

Figure

• 

  Fig. 1 MRI images. A: Brain T2-weighted sagittal sequence showing paranasal sinus obliteration and heterogeneous signal hyperintensities. B: Noncontrast cervical T1-weighted sagittal sequence showing an extra-axial lesion located at the craniocervical junction and extending from the foramen magnum to C2. C: Postcontrast cervical T1-weighted sagittal sequence displaying intense homogeneous contrast uptake. A microscopic examination of the lesion was performed. D: The histiocytes in the infiltrate are large, with abundant, lightly eosinophilic or clear cytoplasm and vesicular nuclei. Hematoxylin and eosin; bar represents 200 µm. E: A histiocytic cell (arrow) engulfing small lymphocytes (emperipolesis). Hematoxylin and eosin; bar represents 200 µm. F: Peripheral nests of meningothelial hyperplasia (arrows). Rosai-Dorfman histiocytic infiltrate in the right lateral border. Hematoxylin and eosin; bar represents 600 µm. G: Abnormal histiocytes showed strong positivity for S-100 protein. H: The histiocytic nature of the cells is highlighted by the immunohistochemical marker CD68. I: The cells were immunohistochemically negative for CD1a.

Reference

1. Chen H, Zhou H, Song Z. Intracranial multifocal Rosai-Dorfman disease. Neurol Neuroimmunol Neuroinflamm. 2016; 3:e293. PMID: 27800534.

2. Tubbs RS, Kelly DR, Mroczek-Musulman EC, Hammers YA, Berkow RL, Oakes WJ, et al. Spinal cord compression as a result of Rosai-Dorfman disease of the upper cervical spine in a child. Childs Nerv Syst. 2005; 21:951–954. PMID: 15650889.

3. Ambekar S, Somanna S, Bhat DI, Ranjan M. Isolated cranio-spinal involvement of Rosai-Dorfman disease: case report. Br J Neurosurg. 2011; 25:297–299. PMID: 20825289.

4. Sandoval-Sus JD, Sandoval-Leon AC, Chapman JR, Velazquez-Vega J, Borja MJ, Rosenberg S, et al. Rosai-Dorfman disease of the central nervous system: report of 6 cases and review of the literature. Medicine (Baltimore). 2014; 93:165–175. PMID: 24797172.