Korean J Blood Transfus.
2017 Aug;28(2):177-182. 10.17945/kjbt.2017.28.2.177.
A Case with Changes in Autoantibodies with Mimicking Specificity in a Patient with Hepatocellular Carcinoma
- Affiliations
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- 1Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. progreen@dau.ac.kr
- 2Department of Laboratory Medicine, Dong-A University Hospital, Busan, Korea.
- KMID: 2391236
- DOI: http://doi.org/10.17945/kjbt.2017.28.2.177
Abstract
- Changes in autoantibodies with mimicking specificity for Rh antigens are quite rare. Here, we report a 73-year-old male patient with hepatocellular carcinoma that showed changes in the autoantibodies with mimicking specificity. He was admitted to our hospital with mental alterations and hypoglycemia. The antibody identification test for RBC transfusion showed a pattern of agglutination, suggesting anti-E alloantibody and anti-c autoantibody. The patient was then diagnosed with hepatocellular carcinoma, and after 18 months, the antibody identification test showed a different pattern of agglutination, suggesting anti-E alloantibody and anti-C autoantibody. We recommend a careful evaluation to make sure an appropriate transfusion is performed when encountering fluctuating autoantibodies with mimicking specificity.
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