Korean J Dermatol.  2002 Jun;40(6):723-726.

Two Cases of Cutaneous Metastasis Originating from Hepatocellular Carcinoma

• Rho NK
• Choi SJ
• Lee ES

Abstract

Hepatocellular carcinoma can metastasize via the blood vessels or the lymphatics and may invade adjacent tissues directly. But skin metastases from primary hepatocellular carcinoma occur rarely, though hepatocellular carcinoma is a common malignancy in Korea. We report cases of cutaneous metastasis in patients with preexisting hepatocellular carcinoma. First patient was a 64-year-old male who had multiple indurated papules and nodules on the scalp. Nodules, which were composed of tumor cells and intervening capillaries, showed characteristic histopathologic features mimicking those of primary hepatocellular carcinoma. The other patient was a 55-year-old female presenting a solitary nodule on the vulva, which showed the histopathology similar to those of the first patient. We discussed these cases with a review of previous reports of skin metastasis from hepatocellular carcinoma.

Keyword

Cutaneous metastasis; Hepatocellular carcinoma

MeSH Terms

Blood Vessels
Capillaries
Carcinoma, Hepatocellular*
Female
Humans
Korea
Male
Middle Aged
Neoplasm Metastasis*
Scalp
Skin
Vulva