J Korean Ophthalmol Soc.  2017 Jul;58(7):828-835. 10.3341/jkos.2017.58.7.828.

The Effectiveness of Selective Laser Trabeculoplasty in Patients with Medically Uncontrolled Open-angle Glaucoma

Affiliations
  • 1The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Korea. unij143@naver.com
  • 3Department of Ophthalmology, Suncheon Medical Center, Suncheon, Korea.

Abstract

PURPOSE
To determine the effect of intraocular pressure (IOP) reduction of selective laser trabeculoplasty (SLT) on medically uncontrolled open-angle glaucoma (OAG) and the factors associated with the treatment result.
METHODS
Forty-seven eyes of 47 OAG patients were enrolled for 180° SLT or 360° SLT, all under maximal tolerated medical therapy and with IOP above their target pressure. All patients were followed-up for at least 1 year after the procedure. Treatment success was defined as IOP reduction ≥20% from baseline at 12 months after SLT treatment without additional anti-glaucomatous intervention.
RESULTS
The treatment success rate was 65.96%. Baseline IOP was 23.84 ± 4.52 mmHg in the success group and 21.44 ± 2.97 mmHg in the failure group (p = 0.035). Significant mean IOP reduction was observed at 6, 9, and 12 month follow-ups (p = 0.001 at 6 months; 0.041 at 9 months, and <0.001 at 12 months). The success rate did not vary significantly by sex (p = 0.362), age (p = 0.081), history of cataract surgery (p = 0.470), number of medications (p = 0.857), duration of medication (p = 0.613), or angular degree of SLT treatment (180° vs. 360°) (p = 0.137). There was a positive correlation between mean baseline IOP and mean reduction of IOP from baseline in the success group (p < 0.001, r = 0.861), while there was no such correlation in the failure group (p = 0.272, r = −2.921).
CONCLUSIONS
SLT was an effective treatment for IOP reduction until 12 months in medically uncontrolled OAG patients. A greater amount of IOP reduction is expected in patients with higher baseline IOP in the success group.

Keyword

Intraocular pressure (IOP); Maximal tolerated medical therapy (MTMT); Selective laser trabeculoplasty (SLT); Uncontrolled glaucoma

MeSH Terms

Cataract
Follow-Up Studies
Glaucoma, Open-Angle*
Humans
Intraocular Pressure
Trabeculectomy*
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