J Korean Ophthalmol Soc.  2010 Jul;51(7):974-980. 10.3341/jkos.2010.51.7.974.

Two-year Follow-up of Selective Laser Trabeculoplasty as Initial and Adjunctive Treatment for Ocular Hypertension and Open Angle Glaucoma

• Moon SJ
• Choi ES
• Park JI
• Lee KH

• KMID: 2213769
• DOI: http://doi.org/10.3341/jkos.2010.51.7.974

Abstract

PURPOSE
To assess the efficacy and safety of selective laser trabeculoplasty (SLT) as initial and adjunctive treatment for ocular hypertension and open angle glaucoma.
METHODS
Twenty-four eyes with ocular hypertension and 63 eyes with open angle glaucoma were treated with a frequency-doubled, Q-switched Nd:YAG laser. Intraocular pressure (IOP) was measured prelaser treatment, one week, one, two, three, six, 12, 18, and 24 months after treatment.
RESULTS
The average pre-laser IOP of 87 eyes was 21.6 mmHg. The mean IOP percent reductions at 1 week, one, two, three, six, 12, 18, and 24 months were 15.3%, 20.0%, 21.3%, 19.6%, 23.4%, 23.4%, 20.5%, and 20.9%, respectively. The IOP percent reductions in the initial treatment group at one, 12, and 24 months were 21.1%, 24.8%, and 22.8% respectively. The IOP percent reductions in the adjunctive treatment group at 1, 12, and 24 months were 19.6%, 22.9%, and 20.2% respectively. There were no differences in IOP percent reduction between the initial treatment group and the adjunctive treatment group.
CONCLUSIONS
Selective laser trabeculoplasty has shown reasonable efficacy in lowering IOP over two-year follow-up period as initial and adjunctive treatment for ocular hypertension and open angle glaucoma.

Keyword

Open angle glaucoma; Ocular hypertension; Selective laser trabeculoplasty

MeSH Terms

Eye
Follow-Up Studies
Glaucoma, Open-Angle
Intraocular Pressure
Ocular Hypertension
Trabeculectomy

Figure

• 

  Figure 1. Mean intraocular pressure of all groups, initial group, adjunctive group during follow-up.

• 

  Figure 2. Mean intraocular pressure according to the numbers of glaucoma medications

• 

  Figure 3. Mean intraocular pressure of bimatoprost group and latanoprost group.

Reference

References

1. Latina MA, Sibayan SA, Shin DH, et al. Q-switched 532-nm Nd:YAG laser trabeculoplasty (selective laser trabeculoplasty): a multi-center, pilot, clinical study. Ophthalmology. 1998; 105:2082–8.

2. Latina MA, Gulati V. Selective laser trabeculoplasty: stimulating the meshwork to mend its ways. Int Ophthalmol Clin. 2004; 44:93–103.

3. Kim JS, Lee YG, Hong YJ. Q-switched frequency doubled Nd:YAG la-ser trabeculoplasty. J Korean Soc. 1999; 40:2591–6.

4. Suhk HJ, Kook MS. Three year follow up of lasertraebculoplasty using Q-switched frequency doubled Nd:YAG laser. J Korean Soc. 2003; 44:1853–9.

5. Lai JS, Chua JK, Tham CC, Lam DS. Five-year follow-up of selective laser trabeculoplasty in Chinese eyes. Clin Experiment Ophthalmol. 2004; 32:368–72.

6. Weinand FS, Althen F. Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma. Eur J Ophthalmol. 2006; 16:100–4.

7. Wise JB, Witter SL. Argon laser therapy for open-angle glaucoma. A pilot study. Arch Ophthalmol. 1979; 97:319–22.

8. The Glaucoma Laser Trial (GLT) and glaucoma laser trial follow-up study: 7. Results. Glaucoma Laser Trial Research Group. Am J Ophthalmol. 1995; 120:718–31.

9. Melamed S, Pei J, Epstein DL. Short-term effect of argon laser trabeculoplasty in monkeys. Arch Ophthalmol. 1985; 103:1546–52.

10. Wise JB. Glaucoma treatment by trabecular tightening with the argon laser. Int Ophthalmol Clin. 1981; 21:69–78.

11. Grayson DK, Camras CB, Podos SM, Lustgarten JS. Long-term reduction of intraocular pressure after repeat argon laser trabeculoplasty. Am J Ophthalmol. 1988; 106:312–21.

12. Richter CU, Shingleton BJ, Bellows AR, et al. Retreatment with argon laser trabeculoplasty. Ophthalmology. 1987; 94:1085–9.

13. Latina MA, Park C. Selective targeting of trabecular meshwork cells: in vitro studies of pulsed and CW laser interactions. Exp Eye Res. 1995; 60:359–71.

14. Latina MA, de Leon JM. Selective laser trabeculoplasty. Ophthalmol Clin North Am. 2005; 18:409–19.

15. Kramer TR, Noecker RJ. Comparison of the morphologic changes after selective laser trabeculoplasty and argon laser trabeculoplasty in human eye bank eyes. Ophthalmology. 2001; 108:773–9.

16. Rozsival P, Kana V, Hovorkova M. Selective laser trabeculoplasty. Ceska Slov Oftalmolo. 2004; 60:267–74.

17. Kim YJ, Moon CS. One – year follow – up of laser trabeculoplasty using Q-switched frequency – doubled Nd:YAG laser of 523 nm wavelength. Ophthalmic Surg Lasers. 2000; 31:394–9.

18. Nagar M, Howes F. Selective laser trabeculoplasty: a new approach to open-angle glaucoma management. American Academy of Ophthalmology Meeting. 2002.

19. Hodge WG, Damji KF, Rock W, et al. Baseline IOP predicts selective laser trabeculoplasty success at 1 year post-treatment: results from a randomised clinical trial. Br J Ophthalmol. 2005; 89:1157–60.

20. Martinez-de-la-Casa JM, Garcia-Feijoo J, Castillo A, et al. Selective vs argon laser trabeculoplasty: hypotensive efficacy, anterior chamber inflammation, and postoperative pain. Eye. 2004; 18:498–502.

21. Damji KF, Bovell AM, Hodge WG, et al. Selective laser trabeculoplasty versus argon laser trabeculoplasty: results from a 1-year randomised clinical trial. Br J Ophthalmol. 2006; 90:1490–4.

22. Popiela G, Muzyka M, Szelepin L. Use of YAG-Selecta laser and argon laser in the treatment of open angle glaucoma. Klin Oczna. 2000; 102:129–33.

23. Scherer WJ. Effect of topical prostaglandin analog use on outcome following selective laser trabeculoplasty. J Ocul Pharmacol Ther. 2007; 23:503–12.

24. Lanzetta P, Menchini U, Virgili G. Immediate intraocular pressure response to selective laser trabeculoplasty. Br J Ophthalmol. 1999; 83:29–32.

25. Johnson PB, Katz LJ, Rhee DJ. Selective laser trabeculoplasty: pre-dictive value of early intraocular pressure measurements for success at 3 months. Br J Ophthalmol. 2006; 90:741–3.

26. Gracner T, Falez M, Gracner B, Pahor D. [Long-term follow-up of selective laser trabeculoplasty in primary open-angle glaucoma]. Klin Monatsbl Augenheilkd. 2006; 223:743–7.

27. Nagar M, Ogunyomade A, O'Brart DP, et al. A randomised, prospective study comparing selective laser trabeculoplasty with latano-prost for the control of intraocular pressure in ocular hypertension and open angle glaucoma. Br J Ophthalmol. 2005; 89:1413–7.

28. Damji KF, Shah KC, Rock WJ, et al. Selective laser trabeculoplasty v argon laser trabeculoplasty: a prospective randomised clinical trial. Br J Ophthalmol. 1999; 83:718–22.