Korean J Anesthesiol.  2017 Aug;70(4):379-389. 10.4097/kjae.2017.70.4.379.

Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y12 inhibitors

Affiliations
  • 1Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA. ktanaka@som.umaryland.edu
  • 2Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Abstract

Platelets play pivotal roles in hemostasis as well as pathological arterial thrombosis. The combination of aspirin and a P2Y₁₂ inhibitor has become the mainstay therapy in the ageing population with cardiovascular conditions, particularly during and after percutaneous coronary intervention. A number of novel P2Y₁₂ inhibitors has become available in the recent years, and they markedly vary in pharmacokinetic and pharmacodynamic properties. Perioperative physicians today face a challenge of preventing hemorrhage due to platelet inhibitors, while minimizing thrombotic risks. There are several point-of-care platelet function tests available in the peri-procedural assessment of residual platelet aggregation. However, these platelet function tests are not standardized in terms of sample processing, agonist type and potency as well as methods of detecting platelet activity. Understanding the differences in pharmacological properties of antiplatelet agents, principles of platelet function tests, and pertinent hemostatic strategies may be useful to anesthesiologists and intensivists who manage perioperative issues associated with antiplatelet agents. The objectives of this review are: 1) to discuss clinical data on aspirin and P2Y12 inhibitors relating to perioperative bleeding, 2) to outline different features of point-of-care platelet function tests, and 3) to discuss therapeutic options for the prevention and treatment of bleeding associated with antiplatelet agents.

Keyword

Antiplatelet therapy; Aspirin; Bleeding; Platelet; P2Y₁₂ inhibitor; Transfusion

MeSH Terms

Aspirin*
Blood Platelets
Hemorrhage
Hemostasis
Percutaneous Coronary Intervention
Platelet Aggregation
Platelet Aggregation Inhibitors*
Platelet Function Tests
Point-of-Care Systems
Thrombosis
Aspirin
Platelet Aggregation Inhibitors
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